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@article{927377,
author = {Češková, Eva and Přikryl, Radovan and Kašpárek, Tomáš},
article_location = {Oslo},
article_number = {1},
doi = {http://dx.doi.org/10.3109/15622975.2010.518625},
keywords = {first episode schizophrenia; symptoms; long term follow up; remission},
language = {eng},
issn = {1562-2975},
journal = {The World Journal of Biological Psychiatry},
title = {Outcome in males with first-episode schizophrenia: 7-year follow-up},
volume = {12},
year = {2011}
}
TY - JOUR
ID - 927377
AU - Češková, Eva - Přikryl, Radovan - Kašpárek, Tomáš
PY - 2011
TI - Outcome in males with first-episode schizophrenia: 7-year follow-up
JF - The World Journal of Biological Psychiatry
VL - 12
IS - 1
SP - 66-72
EP - 66-72
PB - Taylor and Francis
SN - 15622975
KW - first episode schizophrenia
KW - symptoms
KW - long term follow up
KW - remission
N2 - Objectives. The early course of schizophrenia is highly variable. We assessed outcomes of patients with first-episode schizophrenia at 7-year follow-up. Methods. Consecutively hospitalized male patients were included if they were experiencing their first admission for first-episode schizophrenia and were reassessed at 1-, 4- and 7-year follow-ups. The psychopathology was evaluated using the PANSS, relative decrease of PANSS and remission status based on severity of core symptoms. Results. Forty-four of 76 patients were reassessed three times. At the end of index hospitalization 73% of patients achieved remission; however, after 1, 4 and 7 years, the percentage had dropped to 50, 50 and 52%, respectively. When compared post-hoc there was no significant difference in PANSS and response to treatment between remitters and non-remitters during the index hospitalization; however, a significant difference in psychopathology emerged first after 1, 4 and 7 years. All patients who had not achieve remission after 1 year also failed to achieve remission after 4 and 7 years. Conclusions. Response to treatment during the first psychotic break-through may not be a decisive indicator for the outlook of the disease. Our data suggest that when deterioration occurs, it does so early after the first episode.
ER -
ČEŠKOVÁ, Eva, Radovan PŘIKRYL a Tomáš KAŠPÁREK. Outcome in males with first-episode schizophrenia: 7-year follow-up. \textit{The World Journal of Biological Psychiatry}. Oslo: Taylor and Francis, 2011, roč.~12, č.~1, s.~66-72. ISSN~1562-2975. Dostupné z: https://dx.doi.org/10.3109/15622975.2010.518625.
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