| HUDSON, J J R, Kateřina BEDNÁŘOVÁ, Lucie KOZÁKOVÁ, Chunyan LIAO, Marc GUÉRINEAU, Rita COLNAGHI, Susanne VIDOT, Jaromír MAREK, Sreenivas Reddy BATHULA, Alan LEHMANN a Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. PloS ONE. San Francisco: Public Library of Science, 2011, roč. 6, č. 2, s. "nestránkováno", 14 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0017270. |
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@article{928558,
author = {Hudson, J J R and Bednářová, Kateřina and Kozáková, Lucie and Liao, Chunyan and Guérineau, Marc and Colnaghi, Rita and Vidot, Susanne and Marek, Jaromír and Bathula, Sreenivas Reddy and Lehmann, Alan and Paleček, Jan},
article_location = {San Francisco},
article_number = {2},
doi = {http://dx.doi.org/10.1371/journal.pone.0017270},
keywords = {SMC5-6 complex; Nse3/MAGE; Nse4/EID; genome stability; transcription regulation; evolution; placental mammals},
language = {eng},
issn = {1932-6203},
journal = {PloS ONE},
title = {Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families},
url = {http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270},
volume = {6},
year = {2011}
}
TY - JOUR
ID - 928558
AU - Hudson, J J R - Bednářová, Kateřina - Kozáková, Lucie - Liao, Chunyan - Guérineau, Marc - Colnaghi, Rita - Vidot, Susanne - Marek, Jaromír - Bathula, Sreenivas Reddy - Lehmann, Alan - Paleček, Jan
PY - 2011
TI - Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families
JF - PloS ONE
VL - 6
IS - 2
SP - "nestránkováno"
EP - "nestránkováno"
PB - Public Library of Science
SN - 19326203
KW - SMC5-6 complex
KW - Nse3/MAGE
KW - Nse4/EID
KW - genome stability
KW - transcription regulation
KW - evolution
KW - placental mammals
UR - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270
L2 - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270
N2 - The SMC5-6 protein complex is involved in the cellular response to DNA damage. It is composed of 6 - 8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We have identified a conserved hydrophobic surface on the C-terminal domain of Nse3 that interacts with Nse4 and identified residues in its N-terminal domain that are essential for interaction with Nse1. We show that these interactions are conserved in the human orthologs. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that most MAGE proteins can interact with at least one of the NSE4/EID proteins.
ER -
HUDSON, J J R, Kateřina BEDNÁŘOVÁ, Lucie KOZÁKOVÁ, Chunyan LIAO, Marc GUÉRINEAU, Rita COLNAGHI, Susanne VIDOT, Jaromír MAREK, Sreenivas Reddy BATHULA, Alan LEHMANN a Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. \textit{PloS ONE}. San Francisco: Public Library of Science, 2011, roč.~6, č.~2, s.~''nestránkováno'', 14 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0017270.
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