Interactions between the Nse3 and Nse4 Components of the SMC5-6
Complex Identify Evolutionarily Conserved Interactions between
MAGE and EID Families

J 2011

Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families

HUDSON, J J R; Kateřina BEDNÁŘOVÁ; Lucie KOZÁKOVÁ; Chunyan LIAO; Marc GUÉRINEAU et. al.

Basic information

Original name

Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families

Name in Czech

Interakce mezi Nse3 a Nse4 podjednotkami SMC5-6 komplexu ukazují na evoluční konzervaci vazby mezi MAGE a EID proteinovými rodinami

Authors

HUDSON, J J R (826 United Kingdom of Great Britain and Northern Ireland); Kateřina BEDNÁŘOVÁ (203 Czech Republic, belonging to the institution); Lucie KOZÁKOVÁ (203 Czech Republic, belonging to the institution); Chunyan LIAO (826 United Kingdom of Great Britain and Northern Ireland); Marc GUÉRINEAU (250 France, belonging to the institution); Rita COLNAGHI (826 United Kingdom of Great Britain and Northern Ireland); Susanne VIDOT (826 United Kingdom of Great Britain and Northern Ireland); Jaromír MAREK (203 Czech Republic, belonging to the institution); Sreenivas Reddy BATHULA (356 India, belonging to the institution); Alan LEHMANN (826 United Kingdom of Great Britain and Northern Ireland) and Jan PALEČEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

PloS ONE, San Francisco, Public Library of Science, 2011, 1932-6203

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.092

RIV identification code

RIV/00216224:14740/11:00049415

Organization unit

Central European Institute of Technology

DOI

https://doi.org/10.1371/journal.pone.0017270

UT WoS

000287764100039

Keywords in English

SMC5-6 complex; Nse3/MAGE; Nse4/EID; genome stability; transcription regulation; evolution; placental mammals

Abstract

In the original language

The SMC5-6 protein complex is involved in the cellular response to DNA damage. It is composed of 6 - 8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We have identified a conserved hydrophobic surface on the C-terminal domain of Nse3 that interacts with Nse4 and identified residues in its N-terminal domain that are essential for interaction with Nse1. We show that these interactions are conserved in the human orthologs. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that most MAGE proteins can interact with at least one of the NSE4/EID proteins.

Links

GD204/08/H054, research and development project

Name: Molekulární mechanismy proliferace a diferenciace buněk

Investor: Czech Science Foundation, Molecular mechanisms of the cell proliferation and differentiation

IAA501630902, research and development project

Name: Charakterizace MAGE proteinů: kofaktory E3 ubiquitin ligáz?

Investor: Academy of Sciences of the Czech Republic

MSM0021622415, plan (intention)

Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

Cite

HUDSON, J J R; Kateřina BEDNÁŘOVÁ; Lucie KOZÁKOVÁ; Chunyan LIAO; Marc GUÉRINEAU; Rita COLNAGHI; Susanne VIDOT; Jaromír MAREK; Sreenivas Reddy BATHULA; Alan LEHMANN and Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. PloS ONE. San Francisco: Public Library of Science, 2011, vol. 6, No 2, p. "nestránkováno", 14 pp. ISSN 1932-6203. Available from: https://doi.org/10.1371/journal.pone.0017270.

@article{928558,
   author = {Hudson, J J R and Bednářová, Kateřina and Kozáková, Lucie and Liao, Chunyan and Guérineau, Marc and Colnaghi, Rita and Vidot, Susanne and Marek, Jaromír and Bathula, Sreenivas Reddy and Lehmann, Alan and Paleček, Jan},
   article_location = {San Francisco},
   article_number = {2},
   doi = {https://doi.org/10.1371/journal.pone.0017270},
   keywords = {SMC5-6 complex; Nse3/MAGE; Nse4/EID; genome stability; transcription regulation; evolution; placental mammals},
   language = {eng},
   issn = {1932-6203},
   journal = {PloS ONE},
   title = {Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families},
   url = {http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270},
   volume = {6},
   year = {2011}
}

TY  - JOUR
ID  - 928558
AU  - Hudson, J J R - Bednářová, Kateřina - Kozáková, Lucie - Liao, Chunyan - Guérineau, Marc - Colnaghi, Rita - Vidot, Susanne - Marek, Jaromír - Bathula, Sreenivas Reddy - Lehmann, Alan - Paleček, Jan
PY  - 2011
TI  - Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families
JF  - PloS ONE
VL  - 6
IS  - 2
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Public Library of Science
SN  - 19326203
KW  - SMC5-6 complex
KW  - Nse3/MAGE
KW  - Nse4/EID
KW  - genome stability
KW  - transcription regulation
KW  - evolution
KW  - placental mammals
UR  - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270
L2  - http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0017270
N2  - The SMC5-6 protein complex is involved in the cellular response to DNA damage. It is composed of 6 - 8 polypeptides, of which Nse1, Nse3 and Nse4 form a tight sub-complex. MAGEG1, the mammalian ortholog of Nse3, is the founding member of the MAGE (melanoma-associated antigen) protein family and Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We have identified a conserved hydrophobic surface on the C-terminal domain of Nse3 that interacts with Nse4 and identified residues in its N-terminal domain that are essential for interaction with Nse1. We show that these interactions are conserved in the human orthologs. In an examination of the evolutionary conservation of the Nse3-Nse4 interactions, we find that most MAGE proteins can interact with at least one of the NSE4/EID proteins.
ER  -

HUDSON, J J R; Kateřina BEDNÁŘOVÁ; Lucie KOZÁKOVÁ; Chunyan LIAO; Marc GUÉRINEAU; Rita COLNAGHI; Susanne VIDOT; Jaromír MAREK; Sreenivas Reddy BATHULA; Alan LEHMANN and Jan PALEČEK. Interactions between the Nse3 and Nse4 Components of the SMC5-6 Complex Identify Evolutionarily Conserved Interactions between MAGE and EID Families. \textit{PloS ONE}. San Francisco: Public Library of Science, 2011, vol.~6, No~2, p.~''nestránkováno'', 14 pp. ISSN~1932-6203. Available from: https://doi.org/10.1371/journal.pone.0017270.

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