Effect of perphenazine on electrogram of rat isolated heart

J 2011

Effect of perphenazine on electrogram of rat isolated heart

FIALOVÁ, Kateřina; Jiří BLAHÁK; Marek MOTOLA; Jiří JARKOVSKÝ; Jan MUŽÍK et al.

Základní údaje

Originální název

Effect of perphenazine on electrogram of rat isolated heart

Autoři

FIALOVÁ, Kateřina; Jiří BLAHÁK; Marek MOTOLA; Jiří JARKOVSKÝ ; Jan MUŽÍK a Marie NOVÁKOVÁ

Vydání

Acta Veterinaria Brno, Brno, 2011, 0001-7213

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 0.431

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00049756

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.2754/avb201180010087

UT WoS

000289532200012

Klíčová slova česky

Fenothiaziny; Langendorffovo srdce; QT-interval; Arytmie

Klíčová slova anglicky

Phenothiazines; Langendorff heart; QT-interval; Arrhythmia

Příznaky

Mezinárodní význam

Změněno: 20. 4. 2012 15:07, Mgr. Michal Petr

Anotace

V originále

The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant.

Návaznosti

GA102/07/1473, projekt VaV

Název: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Grantová agentura ČR, Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

FIALOVÁ, Kateřina; Jiří BLAHÁK; Marek MOTOLA; Jiří JARKOVSKÝ; Jan MUŽÍK a Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. Acta Veterinaria Brno. Brno, 2011, roč. 80, č. 1, s. 87-92. ISSN 0001-7213. Dostupné z: https://doi.org/10.2754/avb201180010087.

@article{934836,
   author = {Fialová, Kateřina and Blahák, Jiří and Motola, Marek and Jarkovský, Jiří and Mužík, Jan and Nováková, Marie},
   article_location = {Brno},
   article_number = {1},
   doi = {https://doi.org/10.2754/avb201180010087},
   keywords = {Phenothiazines; Langendorff heart; QT-interval; Arrhythmia},
   language = {eng},
   issn = {0001-7213},
   journal = {Acta Veterinaria Brno},
   title = {Effect of perphenazine on electrogram of rat isolated heart},
   volume = {80},
   year = {2011}
}

TY  - JOUR
ID  - 934836
AU  - Fialová, Kateřina - Blahák, Jiří - Motola, Marek - Jarkovský, Jiří - Mužík, Jan - Nováková, Marie
PY  - 2011
TI  - Effect of perphenazine on electrogram of rat isolated heart
JF  - Acta Veterinaria Brno
VL  - 80
IS  - 1
SP  - 87-92
EP  - 87-92
SN  - 00017213
KW  - Phenothiazines
KW  - Langendorff heart
KW  - QT-interval
KW  - Arrhythmia
N2  - The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant.
ER  -

FIALOVÁ, Kateřina; Jiří BLAHÁK; Marek MOTOLA; Jiří JARKOVSKÝ; Jan MUŽÍK a Marie NOVÁKOVÁ. Effect of perphenazine on electrogram of rat isolated heart. \textit{Acta Veterinaria Brno}. Brno, 2011, roč.~80, č.~1, s.~87-92. ISSN~0001-7213. Dostupné z: https://doi.org/10.2754/avb201180010087.

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