Serum neuron-specific enolase concentrations as a predictor of
mortality in children with traumatic brain injury

J 2011

Serum neuron-specific enolase concentrations as a predictor of mortality in children with traumatic brain injury

ŽUREK, Jiří a Michal FEDORA

Základní údaje

Originální název

Serum neuron-specific enolase concentrations as a predictor of mortality in children with traumatic brain injury

Autoři

ŽUREK, Jiří (203 Česká republika, garant, domácí) a Michal FEDORA (203 Česká republika, domácí)

Vydání

Česko-slovenská pediatrie, Praha, Česká lékařská společnost J.E.Purkyně, 2011, 0069-2328

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/11:00052216

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

neuron-specific enolase; traumatic brain injury; biomarker; children

Příznaky

Recenzováno

Změněno: 3. 2. 2012 10:51, Mgr. Michal Petr

Anotace

V originále

The aims of this study were the correlations of neuron-specific enolase (NSE) serum levels and mortality, Glasgow Outcome Scale (GOS) and lenght of hospitalization in children with traumatic brain injury (TBI). Material and method: The study protocol and informed consent were approved by the ethics committee of University Hospital Brno. During the period from May 2007 to October 2009 sixty-three patients with TBI were enrolled into the prospective study. TBI was verified by computerized tomography. Venous blood samples were taken after admission and every 24 h for a maximum of 6 consecutive days. Serum concentrations of neuron-specific enolase were quantified immuno-luminometrically. Six months after the primary injury, the study protocol documented outcome according to the Glasgow Outcome Score. Results: NSE values is significantly higher in patients who died compared to patients who survived. Significantly different dynamics of this protein was only in patients who died while the increase is still noticeable during the first two days. For survivors, the values of this protein decreases from the beginning. At D4 there is a few patients with mild elevation, which, however, does not show as a “second peak” effect in the overall average. In relation to the length of hospitalization does not show any diference. Conclusion: Biomarker neuron-specific enolase may have the potential to be used as quantitative measures of the success of therapy for TBI and might serve as an objective marker of the predictor mortality and outcome.

Citovat

ŽUREK, Jiří a Michal FEDORA. Serum neuron-specific enolase concentrations as a predictor of mortality in children with traumatic brain injury. Česko-slovenská pediatrie. Praha: Česká lékařská společnost J.E.Purkyně, 2011, roč. 66, č. 2, s. 68-74. ISSN 0069-2328.

@article{936358,
   author = {Žurek, Jiří and Fedora, Michal},
   article_location = {Praha},
   article_number = {2},
   keywords = {neuron-specific enolase; traumatic brain injury; biomarker; children},
   language = {eng},
   issn = {0069-2328},
   journal = {Česko-slovenská pediatrie},
   title = {Serum neuron-specific enolase concentrations as a predictor of mortality in children with traumatic brain injury},
   volume = {66},
   year = {2011}
}

TY  - JOUR
ID  - 936358
AU  - Žurek, Jiří - Fedora, Michal
PY  - 2011
TI  - Serum neuron-specific enolase concentrations as a predictor of mortality in children with traumatic brain injury
JF  - Česko-slovenská pediatrie
VL  - 66
IS  - 2
SP  - 68-74
EP  - 68-74
PB  - Česká lékařská společnost J.E.Purkyně
SN  - 00692328
KW  - neuron-specific enolase
KW  - traumatic brain injury
KW  - biomarker
KW  - children
N2  - The aims of this study were the correlations of neuron-specific enolase (NSE) serum levels and mortality, Glasgow Outcome Scale (GOS) and lenght of hospitalization in children with traumatic brain injury (TBI). Material and method: The study protocol and informed consent were approved by the ethics committee of University Hospital Brno. During the period from May 2007 to October 2009 sixty-three patients with TBI were enrolled into the prospective study. TBI was verified by computerized tomography. Venous blood samples were taken after admission and every 24 h for a maximum of 6 consecutive days. Serum concentrations of neuron-specific enolase were quantified immuno-luminometrically. Six months after the primary injury, the study protocol documented outcome according to the Glasgow Outcome Score. Results: NSE values is significantly higher in patients who died compared to patients who survived. Significantly different dynamics of this protein was only in patients who died while the increase is still noticeable during the first two days. For survivors, the values of this protein decreases from the beginning. At D4 there is a few patients with mild elevation, which, however, does not show as a “second peak” effect in the overall average. In relation to the length of hospitalization does not show any diference. Conclusion: Biomarker neuron-specific enolase may have the potential to be used as quantitative measures of the success of therapy for TBI and might serve as an objective marker of the predictor mortality and outcome.
ER  -

ŽUREK, Jiří a Michal FEDORA. Serum neuron-specific enolase concentrations as a predictor of mortality in children with traumatic brain injury. \textit{Česko-slovenská pediatrie}. Praha: Česká lékařská společnost J.E.Purkyně, 2011, roč.~66, č.~2, s.~68-74. ISSN~0069-2328.

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