Local control after tailored surgical treatment of early
cervical cancer

J 2011

Local control after tailored surgical treatment of early cervical cancer

DAVID, Cibula; Ivana PINKAVOVÁ; Ladislav DUŠEK; Jiří SLÁMA; Michal ZIKÁN et. al.

Základní údaje

Originální název

Local control after tailored surgical treatment of early cervical cancer

Autoři

DAVID, Cibula (203 Česká republika, garant); Ivana PINKAVOVÁ (203 Česká republika, domácí); Ladislav DUŠEK (203 Česká republika, domácí); Jiří SLÁMA (203 Česká republika); Michal ZIKÁN (203 Česká republika); Daniela FISCHEROVÁ (203 Česká republika); Pavel FREITAG (203 Česká republika) a Pavel DUNDR (203 Česká republika)

Vydání

International Journal of Gynecologic Cancer, United States, 2011, 1048-891X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.646

Kód RIV

RIV/00216224:14110/11:00052414

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1097/IGC.0b013e318213653d

UT WoS

000290250600017

Klíčová slova anglicky

Cervical cancer; Surgical treatment; Radical hysterectomy; Local control; Survival

Příznaky

Mezinárodní význam

Změněno: 3. 2. 2012 10:12, Mgr. Michal Petr

Anotace

V originále

Background: It was the aim of our study to analyze oncological outcome and prognostic parameters in patients with early stages cervical cancer after tailored and well-standardized surgical treatment with an adequate follow-up. Methods: Oncological outcome and prognostic parameters were evaluated in a group of 192 patients with cervical cancer stages IA2 to 2B who had undergone radical hysterectomy (n = 171), radical parametrectomy (n = 12), or radical trachelectomy (n = 9). Procedures were classified as type B (n = 72), type C1 nerve sparing (n = 103), or type C2 (n = 17). Results: Event-free and overall 5-year survivals probabilities reached 92.7% (confidence interval, 89.5%-95.9 %) and 94.1% (confidence interval, 90.9%-97.3 %). There was only 1 isolated pelvic recurrence found of the total of 10 recurrences. Adjuvant radiotherapy was given to only 22% of patients. The most significant independent prognostic parameters in stage IB tumors were lymph node status, histological type, and tumor volume, whereas in stage II, the parameters included histological type and tumor volume, the latter being inversely related to the prognosis. Conclusions: We have shown an excellent prognosis, especially local control, after tailored surgical treatment of stages IA2 to IIB of cervical cancer, with low prevalence of adjuvant treatment. Different prognostic parameters were observed for stages IB1/IB2 and IIA/B.

Citovat

DAVID, Cibula; Ivana PINKAVOVÁ; Ladislav DUŠEK; Jiří SLÁMA; Michal ZIKÁN; Daniela FISCHEROVÁ; Pavel FREITAG a Pavel DUNDR. Local control after tailored surgical treatment of early cervical cancer. International Journal of Gynecologic Cancer. United States, 2011, roč. 21, č. 4, s. 690-698. ISSN 1048-891X. Dostupné z: https://dx.doi.org/10.1097/IGC.0b013e318213653d.

@article{940734,
   author = {David, Cibula and Pinkavová, Ivana and Dušek, Ladislav and Sláma, Jiří and Zikán, Michal and Fischerová, Daniela and Freitag, Pavel and Dundr, Pavel},
   article_location = {United States},
   article_number = {4},
   doi = {http://dx.doi.org/10.1097/IGC.0b013e318213653d},
   keywords = {Cervical cancer; Surgical treatment; Radical hysterectomy; Local control; Survival},
   language = {eng},
   issn = {1048-891X},
   journal = {International Journal of Gynecologic Cancer},
   title = {Local control after tailored surgical treatment of early cervical cancer},
   volume = {21},
   year = {2011}
}

TY  - JOUR
ID  - 940734
AU  - David, Cibula - Pinkavová, Ivana - Dušek, Ladislav - Sláma, Jiří - Zikán, Michal - Fischerová, Daniela - Freitag, Pavel - Dundr, Pavel
PY  - 2011
TI  - Local control after tailored surgical treatment of early cervical cancer
JF  - International Journal of Gynecologic Cancer
VL  - 21
IS  - 4
SP  - 690-698
EP  - 690-698
SN  - 1048891X
KW  - Cervical cancer
KW  - Surgical treatment
KW  - Radical hysterectomy
KW  - Local control
KW  - Survival
N2  - Background: It was the aim of our study to analyze oncological outcome and prognostic parameters in patients with early stages cervical cancer after tailored and well-standardized surgical treatment with an adequate follow-up. Methods: Oncological outcome and prognostic parameters were evaluated in a group of 192 patients with cervical cancer stages IA2 to 2B who had undergone radical hysterectomy (n = 171), radical parametrectomy (n = 12), or radical trachelectomy (n = 9). Procedures were classified as type B (n = 72), type C1 nerve sparing (n = 103), or type C2 (n = 17). Results: Event-free and overall 5-year survivals probabilities reached 92.7% (confidence interval, 89.5%-95.9 %) and 94.1% (confidence interval, 90.9%-97.3 %). There was only 1 isolated pelvic recurrence found of the total of 10 recurrences. Adjuvant radiotherapy was given to only 22% of patients. The most significant independent prognostic parameters in stage IB tumors were lymph node status, histological type, and tumor volume, whereas in stage II, the parameters included histological type and tumor volume, the latter being inversely related to the prognosis. Conclusions: We have shown an excellent prognosis, especially local control, after tailored surgical treatment of stages IA2 to IIB of cervical cancer, with low prevalence of adjuvant treatment. Different prognostic parameters were observed for stages IB1/IB2 and IIA/B.
ER  -

DAVID, Cibula; Ivana PINKAVOVÁ; Ladislav DUŠEK; Jiří SLÁMA; Michal ZIKÁN; Daniela FISCHEROVÁ; Pavel FREITAG a Pavel DUNDR. Local control after tailored surgical treatment of early cervical cancer. \textit{International Journal of Gynecologic Cancer}. United States, 2011, roč.~21, č.~4, s.~690-698. ISSN~1048-891X. Dostupné z: https://dx.doi.org/10.1097/IGC.0b013e318213653d.

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