Standardised uptake value of 18F-FDG on staging PET CT in newly
diagnosed patients with different subtypes of non-Hodgkin’s
lymphoma

J 2011

Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma

PAPAJÍK, Tomáš; Miroslav MYSLIVEČEK; Zuzana ŠEDOVÁ; Eva BURIÁNKOVÁ; Vít PROCHÁZKA et al.

Základní údaje

Originální název

Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma

Autoři

Vydání

European Journal of Haematology, 2011, 0902-4441

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.614

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00052518

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/j.1600-0609.2010.01532.x

UT WoS

000285302200004

Klíčová slova anglicky

non-Hodgkin’s lymphoma; positron emission tomography; computed tomography; standardised uptake value

Příznaky

Mezinárodní význam

Změněno: 12. 4. 2012 08:14, Mgr. Michal Petr

Anotace

V originále

Objectives: Positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is considered to be the most beneficial imaging method for staging patients with non-Hodgkin’s lymphoma (NHL). The intensity of 18F-FDG accumulation may be determined by calculating the so-called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F-FDG PET CT in untreated patients with NHL. Methods: One hundred and forty-nine initial staging 18F-FDG PET CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined. Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B-cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax lt; 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki-67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P lt; 0.001). The geometric mean of SUVmax in patients with Ki-67 60 and those with Ki-67 gt; 60 was 8.8 and 14.3, respectively (P lt; 0.001). Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki-67 values suggests that SUVmax might have a prognostic values in NHL.

Citovat

PAPAJÍK, Tomáš; Miroslav MYSLIVEČEK; Zuzana ŠEDOVÁ; Eva BURIÁNKOVÁ; Vít PROCHÁZKA; Pavel KORANDA; Luděk RAJDA; Zuzana KUBOVÁ; Miroslava PALOVÁ; Ladislava KUČEROVÁ; Patrik FLODR; Jiří JARKOVSKÝ; Ladislav DUŠEK a Karel INDRÁK. Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma. European Journal of Haematology. 2011, roč. 86, č. 1, s. 32-37. ISSN 0902-4441. Dostupné z: https://doi.org/10.1111/j.1600-0609.2010.01532.x.

@article{942618,
   author = {Papajík, Tomáš and Mysliveček, Miroslav and Šedová, Zuzana and Buriánková, Eva and Procházka, Vít and Koranda, Pavel and Rajda, Luděk and Kubová, Zuzana and Palová, Miroslava and Kučerová, Ladislava and Flodr, Patrik and Jarkovský, Jiří and Dušek, Ladislav and Indrák, Karel},
   article_number = {1},
   doi = {https://doi.org/10.1111/j.1600-0609.2010.01532.x},
   keywords = {non-Hodgkin’s lymphoma; positron emission tomography; computed tomography; standardised uptake value},
   language = {eng},
   issn = {0902-4441},
   journal = {European Journal of Haematology},
   title = {Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma},
   volume = {86},
   year = {2011}
}

TY  - JOUR
ID  - 942618
AU  - Papajík, Tomáš - Mysliveček, Miroslav - Šedová, Zuzana - Buriánková, Eva - Procházka, Vít - Koranda, Pavel - Rajda, Luděk - Kubová, Zuzana - Palová, Miroslava - Kučerová, Ladislava - Flodr, Patrik - Jarkovský, Jiří - Dušek, Ladislav - Indrák, Karel
PY  - 2011
TI  - Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma
JF  - European Journal of Haematology
VL  - 86
IS  - 1
SP  - 32-37
EP  - 32-37
SN  - 09024441
KW  - non-Hodgkin’s lymphoma
KW  - positron emission tomography
KW  - computed tomography
KW  - standardised uptake value
N2  - Objectives: Positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is considered to be the most beneficial imaging method for staging patients with non-Hodgkin’s lymphoma (NHL). The intensity of 18F-FDG accumulation may be determined by calculating the so-called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F-FDG PET CT in untreated patients with NHL. Methods: One hundred and forty-nine initial staging 18F-FDG PET CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined. Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B-cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax lt; 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki-67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P lt; 0.001). The geometric mean of SUVmax in patients with Ki-67 60 and those with Ki-67 gt; 60 was 8.8 and 14.3, respectively (P lt; 0.001). Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki-67 values suggests that SUVmax might have a prognostic values in NHL.
ER  -

PAPAJÍK, Tomáš; Miroslav MYSLIVEČEK; Zuzana ŠEDOVÁ; Eva BURIÁNKOVÁ; Vít PROCHÁZKA; Pavel KORANDA; Luděk RAJDA; Zuzana KUBOVÁ; Miroslava PALOVÁ; Ladislava KUČEROVÁ; Patrik FLODR; Jiří JARKOVSKÝ; Ladislav DUŠEK a Karel INDRÁK. Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma. \textit{European Journal of Haematology}. 2011, roč.~86, č.~1, s.~32-37. ISSN~0902-4441. Dostupné z: https://doi.org/10.1111/j.1600-0609.2010.01532.x.

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