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@proceedings{943460,
author = {Kovářová, Lucie and Varmužová, Tamara and Zarbochová, Pavla and Muthu Raja, Karthick Raja and Suská, Renata and Štossová, Jana and Penka, Miroslav and Hájek, Roman},
booktitle = {16th Congress of the European Hematology Association},
keywords = {flow cytometry; monoclonal gammopathy},
language = {eng},
title = {Clonality assessment using 8-color flow cytometry},
year = {2011}
}
TY - CONF
ID - 943460
AU - Kovářová, Lucie - Varmužová, Tamara - Zarbochová, Pavla - Muthu Raja, Karthick Raja - Suská, Renata - Štossová, Jana - Penka, Miroslav - Hájek, Roman
PY - 2011
TI - Clonality assessment using 8-color flow cytometry
KW - flow cytometry
KW - monoclonal gammopathy
N2 - Background. Monoclonal gammopathies (MG) are characterised by presence of different numbers of clonal plasma cells (PC), lower in monoclonal gammopathy of undetermined significance (MGUS) and higher in multiple myeloma (MM). Discrimination between normal polyclonal PC (N-PC) and abnormal clonal PC (A-PC) is important in time of diagnosis and especially after treatment (transplantation etc.). Expression of surface markers CD19 and CD56 on PCs is widely used for this discrimination, but unfortunately in some cases is not enough sufficient. Aims. Verification and validation of 8-color flow cytometry protocol for clonality assessment of PC and B cell subsets in MGs.Analysis using combination of surface and intracellular markers in 8-color setting can improve detection even small clone of pathological PCs and together with B cell assessment can be very important for determination of diagnosis and monitoring after treatment.
ER -
KOVÁŘOVÁ, Lucie, Tamara VARMUŽOVÁ, Pavla ZARBOCHOVÁ, Karthick Raja MUTHU RAJA, Renata SUSKÁ, Jana ŠTOSSOVÁ, Miroslav PENKA a Roman HÁJEK. Clonality assessment using 8-color flow cytometry. In \textit{16th Congress of the European Hematology Association}. 2011. ISSN~0390-6078.
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