| NĚMEC, Pavel, Fedor KRYUKOV, Elena Vladimirovna DEMENTYEVA, Henrieta GREŠLIKOVÁ, Aneta MIKULÁŠOVÁ, Renata KUPSKÁ, Drahomíra KYJOVSKÁ, Lenka ZAHRADOVÁ, Luděk POUR, Petr KUGLÍK a Roman HÁJEK. Elevated FGFR3 expression as a result of translocation t(4;14) in patients with multiple myeloma. In 13th International Myeloma Workshop. Paris. France. 2011. ISSN 0390-6078. |
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@proceedings{943509,
author = {Němec, Pavel and Kryukov, Fedor and Dementyeva, Elena Vladimirovna and Grešliková, Henrieta and Mikulášová, Aneta and Kupská, Renata and Kyjovská, Drahomíra and Zahradová, Lenka and Pour, Luděk and Kuglík, Petr and Hájek, Roman},
booktitle = {13th International Myeloma Workshop. Paris. France},
keywords = {FGFR3; multiple myeloma; translocation t(4;14)},
language = {eng},
title = {Elevated FGFR3 expression as a result of translocation t(4;14) in patients with multiple myeloma},
year = {2011}
}
TY - CONF
ID - 943509
AU - Němec, Pavel - Kryukov, Fedor - Dementyeva, Elena Vladimirovna - Grešliková, Henrieta - Mikulášová, Aneta - Kupská, Renata - Kyjovská, Drahomíra - Zahradová, Lenka - Pour, Luděk - Kuglík, Petr - Hájek, Roman
PY - 2011
TI - Elevated FGFR3 expression as a result of translocation t(4;14) in patients with multiple myeloma
KW - FGFR3
KW - multiple myeloma
KW - translocation t(4;14)
N2 - Translocation t(4;14) is adverse cytogenetic prognostic factor in patients with MM. Increased expression of FGFR3 gene as a result of t(4;14) (IgH enhancer juxtaposition) was also reported. We analysed FGFR3 gene expression in patients with/without t(4;14). Translocation t(4;14) was evaluated by FISH in MACS separated CD138+ cells obtained from 32 MM patients. Total RNA was transcribed into cDNA (Ambion WT Sense Target assay), labeled and hybridized to the Affymetrix GeneChip Human Gene ST 1.0 array. We anticipate, that the IgH enhancer might be deleted during ilegitimate switch recombination, thus t(4;14) did not always lead into FGFR3 overexpression and patients [with t(4;14)and without FGFR3 overexpression] might represent group of patients with favourable outcome. Our finding should be confirmed by survival analysis in larger cohort.
ER -
NĚMEC, Pavel, Fedor KRYUKOV, Elena Vladimirovna DEMENTYEVA, Henrieta GREŠLIKOVÁ, Aneta MIKULÁŠOVÁ, Renata KUPSKÁ, Drahomíra KYJOVSKÁ, Lenka ZAHRADOVÁ, Luděk POUR, Petr KUGLÍK a Roman HÁJEK. Elevated FGFR3 expression as a result of translocation t(4;14) in patients with multiple myeloma. In \textit{13th International Myeloma Workshop. Paris. France}. 2011. ISSN~0390-6078.
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