| VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT, Vít POSPÍŠIL, Filipp SAVVULIDI, Juraj KOKAVEC, Emanuel NEČAS, Adéla BERKOVÁ, Petra OBRTLÍKOVÁ, Josef KARBAN, Marek MRÁZ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Marek TRNĚNÝ, Jiří ZAVADIL a Tomáš STOPKA. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. Washington, DC , USA: American Society of Hematology, roč. 117, č. 14, s. 3816-3825. ISSN 0006-4971. doi:10.1182/blood-2010-05-285064. 2011. |
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@article{945694,
author = {Vargová, Karin and Curik, Nikola and Burda, Pavel and Bašová, Petra and Kulvait, Vojtěch and Pospíšil, Vít and Savvulidi, Filipp and Kokavec, Juraj and Nečas, Emanuel and Berková, Adéla and Obrtlíková, Petra and Karban, Josef and Mráz, Marek and Pospíšilová, Šárka and Mayer, Jiří and Trněný, Marek and Zavadil, Jiří and Stopka, Tomáš},
article_location = {Washington, DC , USA},
article_number = {14},
doi = {http://dx.doi.org/10.1182/blood-2010-05-285064},
keywords = {MYB; CLL; miR-155 host gene; B-CLL},
language = {eng},
issn = {0006-4971},
journal = {Blood},
title = {MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia},
volume = {117},
year = {2011}
}
TY - JOUR
ID - 945694
AU - Vargová, Karin - Curik, Nikola - Burda, Pavel - Bašová, Petra - Kulvait, Vojtěch - Pospíšil, Vít - Savvulidi, Filipp - Kokavec, Juraj - Nečas, Emanuel - Berková, Adéla - Obrtlíková, Petra - Karban, Josef - Mráz, Marek - Pospíšilová, Šárka - Mayer, Jiří - Trněný, Marek - Zavadil, Jiří - Stopka, Tomáš
PY - 2011
TI - MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia
JF - Blood
VL - 117
IS - 14
SP - 3816-3825
EP - 3816-3825
PB - American Society of Hematology
SN - 00064971
KW - MYB
KW - CLL
KW - miR-155 host gene
KW - B-CLL
N2 - Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription.
ER -
VARGOVÁ, Karin, Nikola CURIK, Pavel BURDA, Petra BAŠOVÁ, Vojtěch KULVAIT, Vít POSPÍŠIL, Filipp SAVVULIDI, Juraj KOKAVEC, Emanuel NEČAS, Adéla BERKOVÁ, Petra OBRTLÍKOVÁ, Josef KARBAN, Marek MRÁZ, Šárka POSPÍŠILOVÁ, Jiří MAYER, Marek TRNĚNÝ, Jiří ZAVADIL a Tomáš STOPKA. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. \textit{Blood}. Washington, DC , USA: American Society of Hematology, roč.~117, č.~14, s.~3816-3825. ISSN~0006-4971. doi:10.1182/blood-2010-05-285064. 2011.
|
