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@book{946796,
author = {Fialová, Kateřina and Nováková, Marie},
address = {Germany},
keywords = {Sigma Receptor; IP3 receptor; antipsychotics; Haloperidol; Perphenazine; Guinea Pig Heart; rat},
language = {eng},
location = {Germany},
isbn = {978-3-8443-8233-4},
publisher = {LAP LAMBERT Academic Publishing},
title = {Effects of sigma receptor ligands in mammalian myocardium},
year = {2011}
}
TY - BOOK
ID - 946796
AU - Fialová, Kateřina - Nováková, Marie
PY - 2011
TI - Effects of sigma receptor ligands in mammalian myocardium
VL - Neuveden
PB - LAP LAMBERT Academic Publishing
CY - Germany
SN - 9783844382334
KW - Sigma Receptor
KW - IP3 receptor
KW - antipsychotics
KW - Haloperidol
KW - Perphenazine
KW - Guinea Pig Heart
KW - rat
N2 - The history of natural as well as medical sciences is full of fascinating stories: some discoveries were caused by mistake and some were actually not firstly perceived as new findings. Discovery and detailed research of sigma receptors belong to such stories undoubtedly. It is a terminated tale - the endogenous ligand was discovered, even if most recently. On the contrary, still some tesseras are missing in this complicated mosaic which such new receptor system represents: it still remains unclear what is their primary role in biological systems and in their regulation. This review is focused on cardiovascular effects of typical representatives of sigma receptor ligands and – at the same time clinically widely used antipsychotics – haloperidol and perphenazine. Use (or even abuse) of various antipsychotics represents worldwide trend within last few decades and thus studies focused on their side effects become a high priority. Moreover, cardiovascular system disorders belong to the most common causes of morbidity and mortality in the developed countries. A significant group of these disorders is represented by side effects of non–cardiovascular drugs.
ER -
FIALOVÁ, Kateřina a Marie NOVÁKOVÁ. \textit{Effects of sigma receptor ligands in mammalian myocardium}. Germany: LAP LAMBERT Academic Publishing, 2011, 156 s. ISBN~978-3-8443-8233-4.
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