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@book{946796, author = {Fialová, Kateřina and Nováková, Marie}, address = {Germany}, keywords = {Sigma Receptor; IP3 receptor; antipsychotics; Haloperidol; Perphenazine; Guinea Pig Heart; rat}, language = {eng}, location = {Germany}, isbn = {978-3-8443-8233-4}, publisher = {LAP LAMBERT Academic Publishing}, title = {Effects of sigma receptor ligands in mammalian myocardium}, year = {2011} }
TY - BOOK ID - 946796 AU - Fialová, Kateřina - Nováková, Marie PY - 2011 TI - Effects of sigma receptor ligands in mammalian myocardium VL - Neuveden PB - LAP LAMBERT Academic Publishing CY - Germany SN - 9783844382334 KW - Sigma Receptor KW - IP3 receptor KW - antipsychotics KW - Haloperidol KW - Perphenazine KW - Guinea Pig Heart KW - rat N2 - The history of natural as well as medical sciences is full of fascinating stories: some discoveries were caused by mistake and some were actually not firstly perceived as new findings. Discovery and detailed research of sigma receptors belong to such stories undoubtedly. It is a terminated tale - the endogenous ligand was discovered, even if most recently. On the contrary, still some tesseras are missing in this complicated mosaic which such new receptor system represents: it still remains unclear what is their primary role in biological systems and in their regulation. This review is focused on cardiovascular effects of typical representatives of sigma receptor ligands and – at the same time clinically widely used antipsychotics – haloperidol and perphenazine. Use (or even abuse) of various antipsychotics represents worldwide trend within last few decades and thus studies focused on their side effects become a high priority. Moreover, cardiovascular system disorders belong to the most common causes of morbidity and mortality in the developed countries. A significant group of these disorders is represented by side effects of non–cardiovascular drugs. ER -
FIALOVÁ, Kateřina a Marie NOVÁKOVÁ. \textit{Effects of sigma receptor ligands in mammalian myocardium}. Germany: LAP LAMBERT Academic Publishing, 2011, 156 s. ISBN~978-3-8443-8233-4.
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