Effects of sigma receptor ligands in mammalian myocardium

B 2011

Effects of sigma receptor ligands in mammalian myocardium

FIALOVÁ, Kateřina a Marie NOVÁKOVÁ

Základní údaje

Originální název

Effects of sigma receptor ligands in mammalian myocardium

Autoři

FIALOVÁ, Kateřina a Marie NOVÁKOVÁ

Vydání

Germany, 156 s. 2011

Nakladatel

LAP LAMBERT Academic Publishing

Další údaje

Jazyk

angličtina

Typ výsledku

Odborná kniha

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00049897

Organizační jednotka

Lékařská fakulta

ISBN

978-3-8443-8233-4

Klíčová slova anglicky

Sigma Receptor; IP3 receptor; antipsychotics; Haloperidol; Perphenazine; Guinea Pig Heart; rat

Změněno: 4. 1. 2012 12:49, Mgr. Michal Petr

Anotace

V originále

The history of natural as well as medical sciences is full of fascinating stories: some discoveries were caused by mistake and some were actually not firstly perceived as new findings. Discovery and detailed research of sigma receptors belong to such stories undoubtedly. It is a terminated tale - the endogenous ligand was discovered, even if most recently. On the contrary, still some tesseras are missing in this complicated mosaic which such new receptor system represents: it still remains unclear what is their primary role in biological systems and in their regulation. This review is focused on cardiovascular effects of typical representatives of sigma receptor ligands and – at the same time clinically widely used antipsychotics – haloperidol and perphenazine. Use (or even abuse) of various antipsychotics represents worldwide trend within last few decades and thus studies focused on their side effects become a high priority. Moreover, cardiovascular system disorders belong to the most common causes of morbidity and mortality in the developed countries. A significant group of these disorders is represented by side effects of non–cardiovascular drugs.

Návaznosti

GA102/07/1473, projekt VaV

Název: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Grantová agentura ČR, Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

Citovat

FIALOVÁ, Kateřina a Marie NOVÁKOVÁ. Effects of sigma receptor ligands in mammalian myocardium. Germany: LAP LAMBERT Academic Publishing, 2011, 156 s. ISBN 978-3-8443-8233-4.

@book{946796,
   author = {Fialová, Kateřina and Nováková, Marie},
   address = {Germany},
   keywords = {Sigma Receptor; IP3 receptor; antipsychotics; Haloperidol; Perphenazine; Guinea Pig Heart; rat},
   language = {eng},
   location = {Germany},
   isbn = {978-3-8443-8233-4},
   publisher = {LAP LAMBERT Academic Publishing},
   title = {Effects of sigma receptor ligands in mammalian myocardium},
   year = {2011}
}

TY  - BOOK
ID  - 946796
AU  - Fialová, Kateřina - Nováková, Marie
PY  - 2011
TI  - Effects of sigma receptor ligands in mammalian myocardium
VL  - Neuveden
PB  - LAP LAMBERT Academic Publishing
CY  - Germany
SN  - 9783844382334
KW  - Sigma Receptor
KW  - IP3 receptor
KW  - antipsychotics
KW  - Haloperidol
KW  - Perphenazine
KW  - Guinea Pig Heart
KW  - rat
N2  - The history of natural as well as medical sciences is full of fascinating stories: some discoveries were caused by mistake and some were actually not firstly perceived as new findings. Discovery and detailed research of sigma receptors belong to such stories undoubtedly. It is a terminated tale - the endogenous ligand was discovered, even if most recently. On the contrary, still some tesseras are missing in this complicated mosaic which such new receptor system represents: it still remains unclear what is their primary role in biological systems and in their regulation. This review is focused on cardiovascular effects of typical representatives of sigma receptor ligands and – at the same time clinically widely used antipsychotics – haloperidol and perphenazine. Use (or even abuse) of various antipsychotics represents worldwide trend within last few decades and thus studies focused on their side effects become a high priority. Moreover, cardiovascular system disorders belong to the most common causes of morbidity and mortality in the developed countries. A significant group of these disorders is represented by side effects of non–cardiovascular drugs.
ER  -

FIALOVÁ, Kateřina a Marie NOVÁKOVÁ. \textit{Effects of sigma receptor ligands in mammalian myocardium}. Germany: LAP LAMBERT Academic Publishing, 2011, 156 s. ISBN~978-3-8443-8233-4.

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