J 2011

Treatment of Deep Vein Thrombosis with Continuous IV Infusion of LMWH: A Retrospective Study in 32 Children

FIAMOLI, Veronika; Jan BLATNÝ; Ondřej ZAPLETAL; Světlana KÖHLEROVÁ; Eva JANOUŠOVÁ et al.

Základní údaje

Originální název

Treatment of Deep Vein Thrombosis with Continuous IV Infusion of LMWH: A Retrospective Study in 32 Children

Autoři

FIAMOLI, Veronika; Jan BLATNÝ; Ondřej ZAPLETAL; Světlana KÖHLEROVÁ a Eva JANOUŠOVÁ

Vydání

Thrombosis, Hindawi Publishing Corporation, 2011, 2090-1488

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00052823

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

deep vein thrombosis; LMWH; risk of thrombosis; antiXa
Změněno: 31. 1. 2014 12:44, RNDr. Eva Koriťáková, Ph.D.

Anotace

V originále

Thirty-two consecutive children aged 0–18 years with VTE treated with LMWH administered as a continuous infusion (CI) were identified at the Children’s University Hospital Brno. The treatment led to at least partial resolution of the thrombus within two weeks in 85% of patients. There were no adverse events or increased bleeding reported in any patients. No recurrences were observed during a followup period of 6 months. Although continuous infusion should not replace subcutaneous (SC) administration of LMWH, CI appeared to be safe and efficient and may provide an alternate method of administering LMWH in a subset of the paediatric population where SC administration may not be feasible. Further prospective studies are needed to support the promising findings of our pilot clinical observation.