Natural Compound Cudraflavone B Shows Promising
Anti-inflammatory Properties in Vitro

J 2011

Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

HOŠEK, Jan; Milan BARTOS; Stanislav CHUDÍK; Stefano DALL’ACQUA; Gabbriella INNOCENTI et al.

Základní údaje

Originální název

Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

Autoři

Vydání

Journal of Natural Products, American Chemical Society, 2011, 0163-3864

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

DOI: 10.1021/np100638h

Impakt faktor

Impact factor: 3.128

Kód RIV

RIV/00216224:14740/11:00052845

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1021/np100638h

UT WoS

000289742300011

Klíčová slova anglicky

Cudraflavone; Morus alba; anti-inflammatory; zinc-finger protein; nonsteroidal drug lead

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 6. 2013 08:25, Olga Křížová

Anotace

V originále

Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor R (TNFR) gene expression and secretion by blocking the translocation of nuclear factor kB (NF-kB) from the cytoplasm to the nucleus inmacrophages derived from a THP-1 human monocyte cell line. Compound 1 acts as a cyclooxygenase (COX-2 and COX-1) inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable antiinflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead.

Návaznosti

LC06030, projekt VaV

Název: Biomolekulární centrum

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Biomolekulární centrum

MSM0021622413, záměr

Název: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Proteiny v metabolismu a při interakci organismů s prostředím

Přiložené soubory

JNP11_74_614.pdf

Požádat o autorskou verzi souboru

Citovat

HOŠEK, Jan; Milan BARTOS; Stanislav CHUDÍK; Stefano DALL’ACQUA; Gabbriella INNOCENTI; Murat KARTAL; Ladislav KOKOŠKA; Peter KOLLÁR; Zsófia KUTIL; Přemysl LANDA; Radek MAREK; Veronika ZÁVALOVÁ; Milan ŽEMLIČKA a Karel ŠMEJKAL. Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro. Journal of Natural Products. American Chemical Society, 2011, roč. 74, č. 4, s. 614-619. ISSN 0163-3864. Dostupné z: https://doi.org/10.1021/np100638h.

@article{947522,
   author = {Hošek, Jan and Bartos, Milan and Chudík, Stanislav and Dall’Acqua, Stefano and Innocenti, Gabbriella and Kartal, Murat and Kokoška, Ladislav and Kollár, Peter and Kutil, Zsófia and Landa, Přemysl and Marek, Radek and Závalová, Veronika and Žemlička, Milan and Šmejkal, Karel},
   article_number = {4},
   doi = {https://doi.org/10.1021/np100638h},
   keywords = {Cudraflavone; Morus alba; anti-inflammatory; zinc-finger protein; nonsteroidal drug lead},
   language = {eng},
   issn = {0163-3864},
   journal = {Journal of Natural Products},
   title = {Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro},
   url = {http://dx.doi.org/10.1021/np100638h},
   volume = {74},
   year = {2011}
}

TY  - JOUR
ID  - 947522
AU  - Hošek, Jan - Bartos, Milan - Chudík, Stanislav - Dall’Acqua, Stefano - Innocenti, Gabbriella - Kartal, Murat - Kokoška, Ladislav - Kollár, Peter - Kutil, Zsófia - Landa, Přemysl - Marek, Radek - Závalová, Veronika - Žemlička, Milan - Šmejkal, Karel
PY  - 2011
TI  - Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro
JF  - Journal of Natural Products
VL  - 74
IS  - 4
SP  - 614-619
EP  - 614-619
PB  - American Chemical Society
SN  - 01633864
KW  - Cudraflavone
KW  - Morus alba
KW  - anti-inflammatory
KW  - zinc-finger protein
KW  - nonsteroidal drug lead
UR  - http://dx.doi.org/10.1021/np100638h
L2  - http://dx.doi.org/10.1021/np100638h
N2  - Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor R (TNFR) gene expression and secretion by blocking the translocation of nuclear factor kB (NF-kB) from the cytoplasm to the nucleus inmacrophages derived from a THP-1 human monocyte cell line. Compound 1 acts as a cyclooxygenase (COX-2 and COX-1) inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable antiinflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead.
ER  -

HOŠEK, Jan; Milan BARTOS; Stanislav CHUDÍK; Stefano DALL’ACQUA; Gabbriella INNOCENTI; Murat KARTAL; Ladislav KOKOŠKA; Peter KOLLÁR; Zsófia KUTIL; Přemysl LANDA; Radek MAREK; Veronika ZÁVALOVÁ; Milan ŽEMLIČKA a Karel ŠMEJKAL. Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro. \textit{Journal of Natural Products}. American Chemical Society, 2011, roč.~74, č.~4, s.~614-619. ISSN~0163-3864. Dostupné z: https://doi.org/10.1021/np100638h.

Přehled o publikaci