Systemic administration of D2 antagonist raclopride inhibits
CYP1A2 in the rat model of isolated perfused liver

J 2011

Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

JUŘICA, Jan; Ondřej ZENDULKA; Roman TRUBAČ a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

Název česky

Systémové podání D2 antagonisty raclopridu inhibuje CYP1A2 v potkaním modelu izolovaných perfundovaných jater

Autoři

JUŘICA, Jan; Ondřej ZENDULKA; Roman TRUBAČ a Alexandra ŠULCOVÁ

Vydání

Activitas Nervosa Superior Rediviva, Praha, Collegium Internationale Activitatis N.S, 2011, 1337-933X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14740/11:00052906

Organizační jednotka

Středoevropský technologický institut

Klíčová slova česky

racloprid; cytochrom P450; izolovaná perfundovaná játra

Klíčová slova anglicky

raclopride; cytochrome P450; isolated perfused rat liver

Štítky

ok, rivok

Změněno: 3. 4. 2012 01:00, Olga Křížová

Anotace

V originále

Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 is a rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek & Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

JUŘICA, Jan; Ondřej ZENDULKA; Roman TRUBAČ a Alexandra ŠULCOVÁ. Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver. Activitas Nervosa Superior Rediviva. Praha: Collegium Internationale Activitatis N.S, 2011, roč. 53, č. 1, s. 32-34. ISSN 1337-933X.

@article{948342,
   author = {Juřica, Jan and Zendulka, Ondřej and Trubač, Roman and Šulcová, Alexandra},
   article_location = {Praha},
   article_number = {1},
   keywords = {raclopride; cytochrome P450; isolated perfused rat liver},
   language = {eng},
   issn = {1337-933X},
   journal = {Activitas Nervosa Superior Rediviva},
   title = {Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver},
   url = {http://www.rediviva.sav.sk/53i1/32.pdf},
   volume = {53},
   year = {2011}
}

TY  - JOUR
ID  - 948342
AU  - Juřica, Jan - Zendulka, Ondřej - Trubač, Roman - Šulcová, Alexandra
PY  - 2011
TI  - Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver
JF  - Activitas Nervosa Superior Rediviva
VL  - 53
IS  - 1
SP  - 32-34
EP  - 32-34
PB  - Collegium Internationale Activitatis N.S
SN  - 1337933X
KW  - raclopride
KW  - cytochrome P450
KW  - isolated perfused rat liver
UR  - http://www.rediviva.sav.sk/53i1/32.pdf
L2  - http://www.rediviva.sav.sk/53i1/32.pdf
N2  - Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 is a rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek & Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics
ER  -

JUŘICA, Jan; Ondřej ZENDULKA; Roman TRUBAČ a Alexandra ŠULCOVÁ. Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver. \textit{Activitas Nervosa Superior Rediviva}. Praha: Collegium Internationale Activitatis N.S, 2011, roč.~53, č.~1, s.~32-34. ISSN~1337-933X.

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