| TROTMAN, Judith, Marion FOURNIER, Thierry LAMY, John Francis SEYMOUR, Anne SONET, Andrea JANÍKOVÁ, Ofer SHPILBERG, Emmanuel GYAN, Hervé TILLY, Jane ESTELL, Cecily FORSYTH, Didier DECAUDIN, Bettina FABIANI, Jean GABARRE, Bruno SALLES, Eric VAN DEN NESTE, Danielle CANIONI, Etienne GARIN, Michael FULHAM, Thierry VANDER BORGHT a Gilles SALLES. Positron Emission Tomography–Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants. Journal of Clinical Oncology. 2011, roč. 29, č. 23, s. 3194-3200. ISSN 0732-183X. Dostupné z: https://dx.doi.org/10.1200/JCO.2011.35.0736. |
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@article{949457,
author = {Trotman, Judith and Fournier, Marion and Lamy, Thierry and Seymour, John Francis and Sonet, Anne and Janíková, Andrea and Shpilberg, Ofer and Gyan, Emmanuel and Tilly, Hervé and Estell, Jane and Forsyth, Cecily and Decaudin, Didier and Fabiani, Bettina and Gabarre, Jean and Salles, Bruno and Van Den Neste, Eric and Canioni, Danielle and Garin, Etienne and Fulham, Michael and Vander Borght, Thierry and Salles, Gilles},
article_number = {23},
doi = {http://dx.doi.org/10.1200/JCO.2011.35.0736},
keywords = {INTERNATIONAL PROGNOSTIC INDEX; NON-HODGKINS-LYMPHOMA; RESPONSE CRITERIA; FOLLOW-UP; FDG-PET; MANAGEMENT; IMPACT; RITUXIMAB; F-18-FDG; SURVIVAL},
language = {eng},
issn = {0732-183X},
journal = {Journal of Clinical Oncology},
title = {Positron Emission Tomography–Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants},
volume = {29},
year = {2011}
}
TY - JOUR
ID - 949457
AU - Trotman, Judith - Fournier, Marion - Lamy, Thierry - Seymour, John Francis - Sonet, Anne - Janíková, Andrea - Shpilberg, Ofer - Gyan, Emmanuel - Tilly, Hervé - Estell, Jane - Forsyth, Cecily - Decaudin, Didier - Fabiani, Bettina - Gabarre, Jean - Salles, Bruno - Van Den Neste, Eric - Canioni, Danielle - Garin, Etienne - Fulham, Michael - Vander Borght, Thierry - Salles, Gilles
PY - 2011
TI - Positron Emission Tomography–Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants
JF - Journal of Clinical Oncology
VL - 29
IS - 23
SP - 3194-3200
EP - 3194-3200
SN - 0732183X
KW - INTERNATIONAL PROGNOSTIC INDEX
KW - NON-HODGKINS-LYMPHOMA
KW - RESPONSE CRITERIA
KW - FOLLOW-UP
KW - FDG-PET
KW - MANAGEMENT
KW - IMPACT
KW - RITUXIMAB
KW - F-18-FDG
KW - SURVIVAL
N2 - The utility of [18F]fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET-CT) in assessing response at the end of induction therapy is well documented in Hodgkin's and diffuse large B-cell lymphomas, but its role in follicular lymphoma (FL) remains undetermined. We investigated the prognostic significance of PET-CT performed after first-line therapy in patients with FL treated in the prospective Primary Rituximab and Maintenance (PRIMA) study. Results of PET-CT scans performed after induction immunochemotherapy were recorded retrospectively. Patients went on to either observation or rituximab maintenance per protocol independent of the PET-CT result. Patient characteristics and outcomes were then evaluated. Of 122 PET-CT scans performed at the end of the induction immunochemotherapy, 32 (26%) were reported as positive by the local investigator. Initial demographic or disease characteristics did not differ between PET-CT–positive (PET-positive) and PET-CT–negative (PET-negative) patients. PET status correlated with conventional response criteria (P < .001). Patients remaining PET positive had a significantly (P < .001) inferior progression-free survival at 42 months of 32.9% (95% CI, 17.2% to 49.5%) compared with 70.7% (95% CI, 59.3% to 79.4%) in those who became PET negative. PET status, but not conventional response (complete response or complete response unconfirmed v partial response) according to IWC 1999, was an independent predictive factor for lymphoma progression. The risk of death was also increased in PET-positive patients (hazard ratio 7.0; P = .0011). [18F]FDG PET-CT status at the end of immunochemotherapy induction in patients with FL is strongly predictive of outcome and should be considered a meaningful clinical end point in future studies.
ER -
TROTMAN, Judith, Marion FOURNIER, Thierry LAMY, John Francis SEYMOUR, Anne SONET, Andrea JANÍKOVÁ, Ofer SHPILBERG, Emmanuel GYAN, Hervé TILLY, Jane ESTELL, Cecily FORSYTH, Didier DECAUDIN, Bettina FABIANI, Jean GABARRE, Bruno SALLES, Eric VAN DEN NESTE, Danielle CANIONI, Etienne GARIN, Michael FULHAM, Thierry VANDER BORGHT a Gilles SALLES. Positron Emission Tomography–Computed Tomography (PET-CT) After Induction Therapy Is Highly Predictive of Patient Outcome in Follicular Lymphoma: Analysis of PET-CT in a Subset of PRIMA Trial Participants. \textit{Journal of Clinical Oncology}. 2011, roč.~29, č.~23, s.~3194-3200. ISSN~0732-183X. Dostupné z: https://dx.doi.org/10.1200/JCO.2011.35.0736.
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