| ŠERÝ, Omar, František ŠŤASTNÝ, Petr ZVOLSKÝ, Zuzana HLINOMAZOVÁ a Vladimír BALCAR. Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients. Neuroscience Letters. Ireland: Elsevier, 2011, roč. 499, č. 3, s. 154 - 157. ISSN 0304-3940. |
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@article{951162,
author = {Šerý, Omar and Šťastný, František and Zvolský, Petr and Hlinomazová, Zuzana and Balcar, Vladimír},
article_location = {Ireland},
article_number = {3},
keywords = {Glutamate; GABA; Retina; BDNF; Alcohol; Genetics of alcoholism},
language = {eng},
issn = {0304-3940},
journal = {Neuroscience Letters},
title = {Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients},
volume = {499},
year = {2011}
}
TY - JOUR
ID - 951162
AU - Šerý, Omar - Šťastný, František - Zvolský, Petr - Hlinomazová, Zuzana - Balcar, Vladimír
PY - 2011
TI - Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients
JF - Neuroscience Letters
VL - 499
IS - 3
SP - 154 - 157
EP - 154 - 157
PB - Elsevier
SN - 03043940
KW - Glutamate
KW - GABA
KW - Retina
KW - BDNF
KW - Alcohol
KW - Genetics of alcoholism
N2 - The BDNF polymorphism Va166Met (rs6265) has been studied in the context of etiology of mental diseases including alcoholism. Alcoholism - a complex disorder known to be linked to several genes - has multiple manifestations, including sensory deficits such as those affecting vision. In the present study we examined a relationship between the Va166Met polymorphism, alcohol dependence and colour vision deficiency (CVD) in 167 alcohol-dependent men and 289 control male subjects. Statistical analysis revealed that almost half (about 48%) of the alcohol dependent men had a CVD. In addition we found that CVD was significantly associated (P = 0.005) with the Va166Met polymorphism. The A allele containing 66Met promotes BDNF expression and this may protect humans against CVD induced by long-term excessive alcohol intake.
ER -
ŠERÝ, Omar, František ŠŤASTNÝ, Petr ZVOLSKÝ, Zuzana HLINOMAZOVÁ a Vladimír BALCAR. Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients. \textit{Neuroscience Letters}. Ireland: Elsevier, 2011, roč.~499, č.~3, s.~154 - 157. ISSN~0304-3940.
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