Bilateral propagation of neuroinflammatory reaction in dorsal
root ganglia alongside the neuroaxis in a neuropathic pain
model

a 2011

Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model

DUBOVÝ, Petr; Ilona KLUSÁKOVÁ; Ivana HRADILOVÁ SVÍŽENSKÁ a Václav BRÁZDA

Základní údaje

Originální název

Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model

Autoři

DUBOVÝ, Petr; Ilona KLUSÁKOVÁ; Ivana HRADILOVÁ SVÍŽENSKÁ a Václav BRÁZDA

Vydání

7th Congress of the European Federation of IASP Chapters (EFIC), 2011

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

ISSN

Klíčová slova česky

neurozánět; TNFa; IL-6; ipsi a kontralaterální spinální ganglia, neuropatická bolest, behaviorální testy

Klíčová slova anglicky

neuroinflamamtory; TNFa, IL-6; ipsi and contralateral dorsal root ganglia; neuropathic pain; behavioral tests

Změněno: 17. 2. 2012 08:06, prof. RNDr. Petr Dubový, CSc.

Anotace

V originále

Background and aims: Compelling evidence indicates that neuropathic pain induced by nerve injury is related to neuroinflammation in the dorsal root ganglia (DRG) containing the primary afferent neurons. The aim of our work was to test whether neuroinflammatory reaction can spread to DRG nonassociated with injured nerve. Results: Although mechanoallodynia and thermal hyperalgesia were detected in the ipsilateral hind paws from 1 to 14 days, only temporal behavioral changes were measured in contralateral hind paws and in fore paws of both sides. However, cytokine proteins and their synthesis were enhanced bilaterally in both cervical and lumbar DRG following CCI. A moderate increase of cytokine proteins and synthesis was also found in DRG from sham-operated animals. Conclusions: Cytokine proteins and their synthesis in DRG per se are not completely correlated with neuropathic pain induction. Cytokine changes in DRG could rather be related to a general neuroinflammatory reaction of the nervous system to injury.

Návaznosti

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

DUBOVÝ, Petr; Ilona KLUSÁKOVÁ; Ivana HRADILOVÁ SVÍŽENSKÁ a Václav BRÁZDA. Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model. In 7th Congress of the European Federation of IASP Chapters (EFIC). 2011. ISSN 1754-3207.

@proceedings{951809,
   author = {Dubový, Petr and Klusáková, Ilona and Hradilová Svíženská, Ivana and Brázda, Václav},
   booktitle = {7th Congress of the European Federation of IASP Chapters (EFIC)},
   keywords = {neuroinflamamtory; TNFa, IL-6; ipsi and contralateral dorsal root ganglia; neuropathic pain; behavioral tests},
   language = {eng},
   title = {Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model},
   year = {2011}
}

TY  - CONF
ID  - 951809
AU  - Dubový, Petr - Klusáková, Ilona - Hradilová Svíženská, Ivana - Brázda, Václav
PY  - 2011
TI  - Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model
KW  - neuroinflamamtory
KW  - TNFa, IL-6
KW  - ipsi and contralateral dorsal root ganglia
KW  - neuropathic pain
KW  - behavioral tests
N2  - Background and aims: Compelling evidence indicates that neuropathic pain induced by nerve injury is related to neuroinflammation in the dorsal root ganglia (DRG) containing the primary afferent neurons. The aim of our work was to test whether neuroinflammatory reaction can spread to DRG nonassociated with injured nerve. Results: Although mechanoallodynia and thermal hyperalgesia were detected in the ipsilateral hind paws from 1 to 14 days, only temporal behavioral changes were measured in contralateral hind paws and in fore paws of both sides. However, cytokine proteins and their synthesis were enhanced bilaterally in both cervical and lumbar DRG following CCI. A moderate increase of cytokine proteins and synthesis was also found in DRG from sham-operated animals. Conclusions: Cytokine proteins and their synthesis in DRG per se are not completely correlated with neuropathic pain induction. Cytokine changes in DRG could rather be related to a general neuroinflammatory reaction of the nervous system to injury.
ER  -

DUBOVÝ, Petr; Ilona KLUSÁKOVÁ; Ivana HRADILOVÁ SVÍŽENSKÁ a Václav BRÁZDA. Bilateral propagation of neuroinflammatory reaction in dorsal root ganglia alongside the neuroaxis in a neuropathic pain model. In \textit{7th Congress of the European Federation of IASP Chapters (EFIC)}. 2011. ISSN~1754-3207.

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