| DOSTÁLEK, Miroslav, Jana PISTOVČÁKOVÁ, Jan JUŘICA, Alexandra ŠULCOVÁ a Josef TOMANDL. The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic. 2011, roč. 155, č. 3, s. 253-257. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2011.047. |
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@article{952508,
author = {Dostálek, Miroslav and Pistovčáková, Jana and Juřica, Jan and Šulcová, Alexandra and Tomandl, Josef},
article_number = {3},
doi = {http://dx.doi.org/10.5507/bp.2011.047},
keywords = {St John‘s wort; Hypericum perforatum; Cytochrome P450; Liver isolated perfused; Rat},
language = {eng},
issn = {1213-8118},
journal = {Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic},
title = {The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver},
url = {http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf},
volume = {155},
year = {2011}
}
TY - JOUR
ID - 952508
AU - Dostálek, Miroslav - Pistovčáková, Jana - Juřica, Jan - Šulcová, Alexandra - Tomandl, Josef
PY - 2011
TI - The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver
JF - Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic
VL - 155
IS - 3
SP - 253-257
EP - 253-257
SN - 12138118
KW - St John‘s wort
KW - Hypericum perforatum
KW - Cytochrome P450
KW - Liver isolated perfused
KW - Rat
UR - http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf
L2 - http://biomed.papers.upol.cz/pdfs/bio/2011/03/05.pdf
N2 - We previously reported the effect of St John’s wort (Hypericum perforatum) standardised extract LI 160 on the activities of cytochrome P450 2C6, 2D2 and 3As (Dostalek et al., Life Sciences 2005;78(3):239-44). In this study, we aimed to assess the effect of St John’s wort on the activity of cytochrome P450 1A2. The isolated perfused rat liver model was used in our experiments with phenacetin as a marker substrate for cytochrome P450 1A2. The rate of formation of acetaminophen was significantly inhibited by the use of St John’s wort. In addition, St John‘s wort extract inhibited cytochrome P450 1A2 activity significantly more than the control inhibitor. St John’s wort significantly inhibited cytochrome P450 1A2 enzyme activity. It remains to be determined whether the co-administration of St John‘s wort extract and other medications or substrates for cytochrome P450 1A2 could result in significant drug interactions.
ER -
DOSTÁLEK, Miroslav, Jana PISTOVČÁKOVÁ, Jan JUŘICA, Alexandra ŠULCOVÁ a Josef TOMANDL. The Effect of St. Johns Wort (Hypericum Perforatum) on Cytochrome P450 1A2 Activity in Perfused Rat Liver. \textit{Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic}. 2011, roč.~155, č.~3, s.~253-257. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2011.047.
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