The predictive value of human organic cation transporter 1 and
ABCB1 expression levels in different cell populations of
patients with de novo chronic myelogenous leukemia

J 2011

The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia

RÁZGA, Filip; Zdeněk RÁČIL; Kateřina MACHOVÁ POLÁKOVÁ; Lucie BUREŠOVÁ; Hana KLAMOVA et. al.

Základní údaje

Originální název

The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia

Název česky

Prediktivní hodnota exprese genů human organic cation transporter 1 a ABCB1v různých buněčných populacích u pacientů s de novo chronickou myeloidní leukémií

Autoři

RÁZGA, Filip; Zdeněk RÁČIL; Kateřina MACHOVÁ POLÁKOVÁ; Lucie BUREŠOVÁ; Hana KLAMOVA; Daniela ŽÁČKOVÁ; Dana DVOŘÁKOVÁ; Václava POLÍVKOVÁ; Petr CETKOVSKÝ a Jiří MAYER

Vydání

International Journal of Hematology, 2011, 0925-5710

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Japonsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.268

Kód RIV

RIV/00216224:14740/11:00053607

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1007/s12185-011-0924-6

UT WoS

000297204800017

Klíčová slova anglicky

human organic cation transporter; ABCB1; chronic myelogenous leukemia

Štítky

ok, rivok

Příznaky

Mezinárodní význam

Změněno: 12. 1. 2012 14:44, Mgr. Michal Petr

Anotace

V originále

In this study, we investigated the predictive value of pretreatment mRNA expression levels of hOCT-1 and ABCB1 in different cell populations with regard to the response to therapy at 6 and 12 months of IMA therapy. Expression levels were assessed in peripheral blood (PB) leukocytes (LEU, n = 30), polymorphonuclear cells (PMNC, n = 23), and mononuclear cells (MNC, n = 21) of PB LEU obtained from 30 patients with de novo chronic myelogenous leukemia (CML). Moreover, the available bone marrow cells (BM) were also included and analyzed (BM, n = 11). The PB and BM samples were obtained, processed, and analyzed as previously described. Responses to therapy were classified according the European LeukemiaNet 2009 (ELN) criteria: responders show an optimal response at 6 months and 12 months, while non-responders reflect a suboptimal response or therapy failure. The assessed pretreatment expression levels were stratified into two groups according to the median-a low-mRNA expression group below the median and a high-mRNA expression group equal to or above the median. The statistical evaluation of the data obtained was performed using the Fisher’s exact tests and summarized in Table 2.

Návaznosti

MSM0021622430, záměr

Název: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Citovat

RÁZGA, Filip; Zdeněk RÁČIL; Kateřina MACHOVÁ POLÁKOVÁ; Lucie BUREŠOVÁ; Hana KLAMOVA; Daniela ŽÁČKOVÁ; Dana DVOŘÁKOVÁ; Václava POLÍVKOVÁ; Petr CETKOVSKÝ a Jiří MAYER. The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia. International Journal of Hematology. 2011, roč. 94, č. 3, s. 303-306. ISSN 0925-5710. Dostupné z: https://doi.org/10.1007/s12185-011-0924-6.

@article{954192,
   author = {Rázga, Filip and Ráčil, Zdeněk and Machová Poláková, Kateřina and Burešová, Lucie and Klamova, Hana and Žáčková, Daniela and Dvořáková, Dana and Polívková, Václava and Cetkovský, Petr and Mayer, Jiří},
   article_number = {3},
   doi = {https://doi.org/10.1007/s12185-011-0924-6},
   keywords = {human organic cation transporter; ABCB1; chronic myelogenous leukemia},
   language = {eng},
   issn = {0925-5710},
   journal = {International Journal of Hematology},
   title = {The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia},
   volume = {94},
   year = {2011}
}

TY  - JOUR
ID  - 954192
AU  - Rázga, Filip - Ráčil, Zdeněk - Machová Poláková, Kateřina - Burešová, Lucie - Klamova, Hana - Žáčková, Daniela - Dvořáková, Dana - Polívková, Václava - Cetkovský, Petr - Mayer, Jiří
PY  - 2011
TI  - The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia
JF  - International Journal of Hematology
VL  - 94
IS  - 3
SP  - 303-306
EP  - 303-306
SN  - 09255710
KW  - human organic cation transporter
KW  - ABCB1
KW  - chronic myelogenous leukemia
N2  - In this study, we investigated the predictive value of pretreatment mRNA expression levels of hOCT-1 and ABCB1 in different cell populations with regard to the response to therapy at 6 and 12 months of IMA therapy. Expression levels were assessed in peripheral blood (PB) leukocytes (LEU, n = 30), polymorphonuclear cells (PMNC, n = 23), and mononuclear cells (MNC, n = 21) of PB LEU obtained from 30 patients with de novo chronic myelogenous leukemia (CML). Moreover, the available bone marrow cells (BM) were also included and analyzed (BM, n = 11). The PB and BM samples were obtained, processed, and analyzed as previously described. Responses to therapy were classified according the European LeukemiaNet 2009 (ELN) criteria: responders show an optimal response at 6 months and 12 months, while non-responders reflect a suboptimal response or therapy failure. The assessed pretreatment expression levels were stratified into two groups according to the median-a low-mRNA expression group below the median and a high-mRNA expression group equal to or above the median. The statistical evaluation of the data obtained was performed using the Fisher’s exact tests and summarized in Table 2.
ER  -

RÁZGA, Filip; Zdeněk RÁČIL; Kateřina MACHOVÁ POLÁKOVÁ; Lucie BUREŠOVÁ; Hana KLAMOVA; Daniela ŽÁČKOVÁ; Dana DVOŘÁKOVÁ; Václava POLÍVKOVÁ; Petr CETKOVSKÝ a Jiří MAYER. The predictive value of human organic cation transporter 1 and ABCB1 expression levels in different cell populations of patients with de novo chronic myelogenous leukemia. \textit{International Journal of Hematology}. 2011, roč.~94, č.~3, s.~303-306. ISSN~0925-5710. Dostupné z: https://doi.org/10.1007/s12185-011-0924-6.

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