| ŠVÁCHOVÁ, Hana, Luděk POUR, Jiří ŠÁNA, Lucie ŘÍHOVÁ, Karthick Raja MUTHU RAJA a Roman HÁJEK. Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients. Leukemia Research. 2011, roč. 35, č. 8, s. 1008-1013. ISSN 0145-2126. Dostupné z: https://dx.doi.org/10.1016/j.leukres.2011.03.001. |
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@article{955987,
author = {Šváchová, Hana and Pour, Luděk and Šána, Jiří and Říhová, Lucie and Muthu Raja, Karthick Raja and Hájek, Roman},
article_number = {8},
doi = {http://dx.doi.org/10.1016/j.leukres.2011.03.001},
keywords = {Nestin; Plasma cells; Multiple myeloma; Myeloma stem cells; Flow cytometry},
language = {eng},
issn = {0145-2126},
journal = {Leukemia Research},
title = {Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients},
volume = {35},
year = {2011}
}
TY - JOUR
ID - 955987
AU - Šváchová, Hana - Pour, Luděk - Šána, Jiří - Říhová, Lucie - Muthu Raja, Karthick Raja - Hájek, Roman
PY - 2011
TI - Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients
JF - Leukemia Research
VL - 35
IS - 8
SP - 1008-1013
EP - 1008-1013
SN - 01452126
KW - Nestin
KW - Plasma cells
KW - Multiple myeloma
KW - Myeloma stem cells
KW - Flow cytometry
N2 - Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma.
ER -
ŠVÁCHOVÁ, Hana, Luděk POUR, Jiří ŠÁNA, Lucie ŘÍHOVÁ, Karthick Raja MUTHU RAJA a Roman HÁJEK. Stem cell marker nestin is expressed in plasma cells of multiple myeloma patients. \textit{Leukemia Research}. 2011, roč.~35, č.~8, s.~1008-1013. ISSN~0145-2126. Dostupné z: https://dx.doi.org/10.1016/j.leukres.2011.03.001.
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