Does previous hypertension affect outcome in acute heart
failure?

J 2011

Does previous hypertension affect outcome in acute heart failure?

FELŠŐCI, Marián, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Petr WIDIMSKÝ et. al.

Základní údaje

Originální název

Does previous hypertension affect outcome in acute heart failure?

Autoři

FELŠŐCI, Marián (703 Slovensko, garant, domácí), Jiří PAŘENICA (203 Česká republika, domácí), Jindřich ŠPINAR (203 Česká republika, domácí), Jiří VÍTOVEC (203 Česká republika, domácí), Petr WIDIMSKÝ (203 Česká republika), Aleš LINHART (203 Česká republika), Marián FEDORCO (703 Slovensko), Filip MÁLEK (203 Česká republika), Čestmír ČÍHALÍK (203 Česká republika), Roman MIKLÍK (203 Česká republika, domácí) a Jiří JARKOVSKÝ (203 Česká republika, domácí)

Vydání

European Journal of Internal Medicine, 2011, 0953-6205

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.000

Kód RIV

RIV/00216224:14110/11:00053764

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ejim.2011.09.006

UT WoS

000296762000041

Klíčová slova anglicky

Hypertension; Blood pressure; Acute heart failure; Outcome; Mortality

Příznaky

Mezinárodní význam

Změněno: 23. 3. 2012 13:46, Mgr. Michal Petr

Anotace

V originále

The effect of previous long-term hypertension on mortality in acute heart failure (HF), regardless of blood pressure values, has not been well studied. Acute Heart Failure Database (AHEAD) - Czech HF registry enrolled 4153 consecutive patients with acute HF. We excluded severe forms (cardiogenic shock, pulmonary oedema, right HF) and analysed 2421 patientswith known presence or absence of previous hypertension. Demographic, clinical and laboratory profile, treatment and mortality rates were assessed and predictors of outcome were identified. Patients with previous hypertension (71.5%) were older, more of female gender, with worse prehospitalisation NYHA class, increased incidence of co-morbidities and higher left ventricular ejection fraction (LVEF). Although in-hospital mortality was similar in both cohorts, survival at 1, 2 and 3-year was worse in the hypertensive group. Nevertheless, hypertension was not associated with mortality in multivariate analysis and stronger predictors of outcome were identified (Pb0.05): new-onset acute HF [hazard ratio (HR) 0.62] and increased body mass index (HR 0.68) proved to have a protective role. Advanced age (HR 1.86), diabetes (HR 1.45), lower LVEF (HR 1.28) and admission blood pressure (HR 1.54), elevated serum creatinine (HR 1.63), hyponatremia (HR 1.77) and anaemia (HR 1.40) were associated with worse survival. Conclusion: Antecedent hypertension is frequent in patients with acute HF and contributes to organ and vascular impairment. However its presence has no independent influence on short- and medium-term mortality, which is influenced by other related co-morbidities.

Návaznosti

MSM0021622402, záměr

Název: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Časná diagnostika a léčba kardiovaskulárních chorob

NS9880, projekt VaV

Název: Komplexní managment péče o pacienty as akutním srdečním selháním, jejichstřednědobá prognóza a multivariantní prognostický model

Investor: Ministerstvo zdravotnictví ČR, Komplexní managenent péče o pacienty s akutním srdečním selháním, jejich střednědobá prognóza a multivariantní prognostický model

Citovat

FELŠŐCI, Marián, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Petr WIDIMSKÝ, Aleš LINHART, Marián FEDORCO, Filip MÁLEK, Čestmír ČÍHALÍK, Roman MIKLÍK a Jiří JARKOVSKÝ. Does previous hypertension affect outcome in acute heart failure? European Journal of Internal Medicine. 2011, roč. 22, č. 6, s. 591-596. ISSN 0953-6205. Dostupné z: https://dx.doi.org/10.1016/j.ejim.2011.09.006.

@article{956065,
   author = {Felšőci, Marián and Pařenica, Jiří and Špinar, Jindřich and Vítovec, Jiří and Widimský, Petr and Linhart, Aleš and Fedorco, Marián and Málek, Filip and Číhalík, Čestmír and Miklík, Roman and Jarkovský, Jiří},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.ejim.2011.09.006},
   keywords = {Hypertension; Blood pressure; Acute heart failure; Outcome; Mortality},
   language = {eng},
   issn = {0953-6205},
   journal = {European Journal of Internal Medicine},
   title = {Does previous hypertension affect outcome in acute heart failure?},
   volume = {22},
   year = {2011}
}

TY  - JOUR
ID  - 956065
AU  - Felšőci, Marián - Pařenica, Jiří - Špinar, Jindřich - Vítovec, Jiří - Widimský, Petr - Linhart, Aleš - Fedorco, Marián - Málek, Filip - Číhalík, Čestmír - Miklík, Roman - Jarkovský, Jiří
PY  - 2011
TI  - Does previous hypertension affect outcome in acute heart failure?
JF  - European Journal of Internal Medicine
VL  - 22
IS  - 6
SP  - 591-596
EP  - 591-596
SN  - 09536205
KW  - Hypertension
KW  - Blood pressure
KW  - Acute heart failure
KW  - Outcome
KW  - Mortality
N2  - The effect of previous long-term hypertension on mortality in acute heart failure (HF), regardless of blood pressure values, has not been well studied. Acute Heart Failure Database (AHEAD) - Czech HF registry enrolled 4153 consecutive patients with acute HF. We excluded severe forms (cardiogenic shock, pulmonary oedema, right HF) and analysed 2421 patientswith known presence or absence of previous hypertension. Demographic, clinical and laboratory profile, treatment and mortality rates were assessed and predictors of outcome were identified. Patients with previous hypertension (71.5%) were older, more of female gender, with worse prehospitalisation NYHA class, increased incidence of co-morbidities and higher left ventricular ejection fraction (LVEF). Although in-hospital mortality was similar in both cohorts, survival at 1, 2 and 3-year was worse in the hypertensive group. Nevertheless, hypertension was not associated with mortality in multivariate analysis and stronger predictors of outcome were identified (Pb0.05): new-onset acute HF [hazard ratio (HR) 0.62] and increased body mass index (HR 0.68) proved to have a protective role. Advanced age (HR 1.86), diabetes (HR 1.45), lower LVEF (HR 1.28) and admission blood pressure (HR 1.54), elevated serum creatinine (HR 1.63), hyponatremia (HR 1.77) and anaemia (HR 1.40) were associated with worse survival. Conclusion: Antecedent hypertension is frequent in patients with acute HF and contributes to organ and vascular impairment. However its presence has no independent influence on short- and medium-term mortality, which is influenced by other related co-morbidities.
ER  -

FELŠ$\backslash$H OCI, Marián, Jiří PAŘENICA, Jindřich ŠPINAR, Jiří VÍTOVEC, Petr WIDIMSKÝ, Aleš LINHART, Marián FEDORCO, Filip MÁLEK, Čestmír ČÍHALÍK, Roman MIKLÍK a Jiří JARKOVSKÝ. Does previous hypertension affect outcome in acute heart failure? \textit{European Journal of Internal Medicine}. 2011, roč.~22, č.~6, s.~591-596. ISSN~0953-6205. Dostupné z: https://dx.doi.org/10.1016/j.ejim.2011.09.006.

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