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@article{956243,
author = {Horák, Jakub and Janda, Lubomír and Pekárová, Blanka and Hejátko, Jan},
article_number = {2},
keywords = {Arabidopsis thaliana; cytokinin; phosphorelay; plant hormone; signal integration; signal specificity; signalling pathway; two-component system},
language = {eng},
issn = {1389-2037},
journal = {CURRENT PROTEIN & PEPTIDE SCIENCE},
title = {Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis},
volume = {12},
year = {2011}
}
TY - JOUR
ID - 956243
AU - Horák, Jakub - Janda, Lubomír - Pekárová, Blanka - Hejátko, Jan
PY - 2011
TI - Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis
JF - CURRENT PROTEIN & PEPTIDE SCIENCE
VL - 12
IS - 2
SP - 126-136
EP - 126-136
PB - Bentham Science Publishers
SN - 13892037
KW - Arabidopsis thaliana
KW - cytokinin
KW - phosphorelay
KW - plant hormone
KW - signal integration
KW - signal specificity
KW - signalling pathway
KW - two-component system
N2 - Multistep phosphorelay (MSP) pathways mediate a wide spectrum of adaptive responses in plants, including hormonal and abiotic stress regulations. Recent genetic evidence suggests both partial redundancy and possible functional cross-talk on the one hand and a certain level of specificity on the other. Here, we discuss recent achievements improving our understanding of possible molecular mechanisms of specificity in MSP. We consider a certain evolutionary conservation of ancestral two-component signalling systems from bacteria in a process of molecular recognition that, as we have recently shown, could be applied also to a certain extent in the case of plant MSP. Furthermore, we discuss possible roles of kinase and phosphatase activities, kinetics of both these enzymatic reactions, and phosphorylation lifetime. We include also recent findings on the expression specificity of individual members of MSP pathways and, finally, based on our recent findings, we speculate about a possible role of magnesium in regulation of MSP pathways in plants. All these mechanisms could significantly influence specificity and signalling output of the MSP pathways.
ER -
HORÁK, Jakub, Lubomír JANDA, Blanka PEKÁROVÁ a Jan HEJÁTKO. Molecular Mechanisms of Signalling Specificity via Phosphorelay Pathways in Arabidopsis. \textit{CURRENT PROTEIN \&{} PEPTIDE SCIENCE}. Bentham Science Publishers, roč.~12, č.~2, s.~126-136. ISSN~1389-2037. 2011.
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