A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam,
Administered Shortly after Irradiation Increases Survival of
Lethally Irradiated Mice

J 2011

A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice

HOFER, M.; M. POSPÍŠIL; Ladislav DUŠEK; Z. HOFEROVÁ; L. WEITEROVÁ et al.

Základní údaje

Originální název

A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice

Autoři

HOFER, M.; M. POSPÍŠIL; Ladislav DUŠEK; Z. HOFEROVÁ a L. WEITEROVÁ

Vydání

Radiation Research, 2011, 0033-7587

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10610 Biophysics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.684

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00050181

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1667/RR2614.1

UT WoS

000293682100014

Klíčová slova anglicky

GAMMA-IRRADIATION; HEMATOPOIETIC RECOVERY; G-CSF; INDOMETHACIN; TOXICITY

Příznaky

Mezinárodní význam

Změněno: 20. 4. 2012 12:06, Mgr. Michal Petr

Anotace

V originále

This study extends earlier findings of the authors demonstrating that meloxicam, a selective inhibitor of cyclooxygenase 2, supports hematopoietic recovery in sublethally irradiated mice and is radioprotective when given before irradiation. We report here that when meloxicam was administered in a single dose 1 h after a lethal 9-Gy whole-body dose, an increased 30-day survival was achieved. Additional studies showed that administration of meloxicam 24 h after lethal irradiation is ineffective and its repeated administration deleterious. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed.

Návaznosti

GA305/08/0158, projekt VaV

Název: Aktivace adenosinových receptorů kombinovaná s inhibicí cyklooxygenázy v modulaci zářením vyvolaného poškození kostní dřeně

Investor: Grantová agentura ČR, Aktivace adenosinových receptorů kompbinovaná s inhibicí cyklooxygenázy v modulaci zářením vyvolavaného poškození kostní dřeně

Citovat

HOFER, M.; M. POSPÍŠIL; Ladislav DUŠEK; Z. HOFEROVÁ a L. WEITEROVÁ. A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice. Radiation Research. 2011, roč. 176, č. 2, s. 269-272. ISSN 0033-7587. Dostupné z: https://doi.org/10.1667/RR2614.1.

@article{959950,
   author = {Hofer, M. and Pospíšil, M. and Dušek, Ladislav and Hoferová, Z. and Weiterová, L.},
   article_number = {2},
   doi = {https://doi.org/10.1667/RR2614.1},
   keywords = {GAMMA-IRRADIATION; HEMATOPOIETIC RECOVERY; G-CSF; INDOMETHACIN; TOXICITY},
   language = {eng},
   issn = {0033-7587},
   journal = {Radiation Research},
   title = {A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice},
   volume = {176},
   year = {2011}
}

TY  - JOUR
ID  - 959950
AU  - Hofer, M. - Pospíšil, M. - Dušek, Ladislav - Hoferová, Z. - Weiterová, L.
PY  - 2011
TI  - A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice
JF  - Radiation Research
VL  - 176
IS  - 2
SP  - 269-272
EP  - 269-272
SN  - 00337587
KW  - GAMMA-IRRADIATION
KW  - HEMATOPOIETIC RECOVERY
KW  - G-CSF
KW  - INDOMETHACIN
KW  - TOXICITY
N2  - This study extends earlier findings of the authors demonstrating that meloxicam, a selective inhibitor of cyclooxygenase 2, supports hematopoietic recovery in sublethally irradiated mice and is radioprotective when given before irradiation. We report here that when meloxicam was administered in a single dose 1 h after a lethal 9-Gy whole-body dose, an increased 30-day survival was achieved. Additional studies showed that administration of meloxicam 24 h after lethal irradiation is ineffective and its repeated administration deleterious. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed.
ER  -

HOFER, M.; M. POSPÍŠIL; Ladislav DUŠEK; Z. HOFEROVÁ a L. WEITEROVÁ. A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice. \textit{Radiation Research}. 2011, roč.~176, č.~2, s.~269-272. ISSN~0033-7587. Dostupné z: https://doi.org/10.1667/RR2614.1.

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