No association of promoter variations of HMOX1 and UGT1A1 genes
with liver injury in chronic hepatitis C

J 2011

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

URBÁNEK, Petr; Martin LENÍČEK; Lucie MUCHOVÁ; Iva SUBHANOVÁ; Ladislav DUŠEK et al.

Základní údaje

Originální název

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Autoři

URBÁNEK, Petr; Martin LENÍČEK; Lucie MUCHOVÁ; Iva SUBHANOVÁ; Ladislav DUŠEK; Nikola KASPŘÍKOVÁ; Petr HRABAL; Radan BRUHA a Libor VÍTEK

Vydání

Annals of Hepatology, 2011, 1665-2681

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Mexiko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.811

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00054111

Organizační jednotka

Lékařská fakulta

UT WoS

000296672600005

Klíčová slova anglicky

Bilirubin; Bilirubin UDP-glucuronosyltransferase; Genetic predisposition; Heme oxygenase; Oxidative stress

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 2. 2012 15:44, Mgr. Michal Petr

Anotace

V originále

Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense. Objective. To assess the effect of promotervariations of HMOX1 and UGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). Material and methods. The study was performed on146 chronic HCV infection patients, plus 146 age- and sex-matched healthy subjects. The (GT)n and (TA)n dinucleotide variations in HMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis in all subjects. Results. No differences were found in the frequencies of each particular allele of both genes, between HCV patients and a control group (p > 0.05). Furthermore, no association was detected (p > 0.05) between either the HMOX1 or the UGT1A1 promoter variants and the individual histological stages of liver disease in the HCV positive patients. Finally, no differences in the HMOX1 and UGT1A1 genotype prevalence rates were found between pre-cirrhotic and cirrhotic patients (p > 0.05). Conclusion. Based on our data, microsatellite variations in the HMOX1 and UGT1A1 genes are not likely to protect from progression of liver disease in patients with chronic hepatitis C.

Citovat

URBÁNEK, Petr; Martin LENÍČEK; Lucie MUCHOVÁ; Iva SUBHANOVÁ; Ladislav DUŠEK; Nikola KASPŘÍKOVÁ; Petr HRABAL; Radan BRUHA a Libor VÍTEK. No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C. Annals of Hepatology. 2011, roč. 10, č. 4, s. 445-451. ISSN 1665-2681.

@article{959953,
   author = {Urbánek, Petr and Leníček, Martin and Muchová, Lucie and Subhanová, Iva and Dušek, Ladislav and Kaspříková, Nikola and Hrabal, Petr and Bruha, Radan and Vítek, Libor},
   article_number = {4},
   keywords = {Bilirubin; Bilirubin UDP-glucuronosyltransferase; Genetic predisposition; Heme oxygenase; Oxidative stress},
   language = {eng},
   issn = {1665-2681},
   journal = {Annals of Hepatology},
   title = {No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C},
   volume = {10},
   year = {2011}
}

TY  - JOUR
ID  - 959953
AU  - Urbánek, Petr - Leníček, Martin - Muchová, Lucie - Subhanová, Iva - Dušek, Ladislav - Kaspříková, Nikola - Hrabal, Petr - Bruha, Radan - Vítek, Libor
PY  - 2011
TI  - No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C
JF  - Annals of Hepatology
VL  - 10
IS  - 4
SP  - 445-451
EP  - 445-451
SN  - 16652681
KW  - Bilirubin
KW  - Bilirubin UDP-glucuronosyltransferase
KW  - Genetic predisposition
KW  - Heme oxygenase
KW  - Oxidative stress
N2  - Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense. Objective. To assess the effect of promotervariations of HMOX1 and UGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). Material and methods. The study was performed on146 chronic HCV infection patients, plus 146 age- and sex-matched healthy subjects. The (GT)n and (TA)n dinucleotide variations in HMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis in all subjects. Results. No differences were found in the frequencies of each particular allele of both genes, between HCV patients and a control group (p > 0.05). Furthermore, no association was detected (p > 0.05) between either the HMOX1 or the UGT1A1 promoter variants and the individual histological stages of liver disease in the HCV positive patients. Finally, no differences in the HMOX1 and UGT1A1 genotype prevalence rates were found between pre-cirrhotic and cirrhotic patients (p > 0.05). Conclusion. Based on our data, microsatellite variations in the HMOX1 and UGT1A1 genes are not likely to protect from progression of liver disease in patients with chronic hepatitis C.
ER  -

URBÁNEK, Petr; Martin LENÍČEK; Lucie MUCHOVÁ; Iva SUBHANOVÁ; Ladislav DUŠEK; Nikola KASPŘÍKOVÁ; Petr HRABAL; Radan BRUHA a Libor VÍTEK. No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C. \textit{Annals of Hepatology}. 2011, roč.~10, č.~4, s.~445-451. ISSN~1665-2681.

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