Identification and functional studies on proteins involved in
in low-grade breast cancer metastasis

a 2011

Identification and functional studies on proteins involved in in low-grade breast cancer metastasis

DVOŘÁKOVÁ, Monika; Petr MÜLLER; Lenka HERNYCHOVÁ; Spiros D. GARBIS; Rudolf NENUTIL et al.

Základní údaje

Originální název

Identification and functional studies on proteins involved in in low-grade breast cancer metastasis

Autoři

DVOŘÁKOVÁ, Monika; Petr MÜLLER; Lenka HERNYCHOVÁ; Spiros D. GARBIS; Rudolf NENUTIL; Bořivoj VOJTĚŠEK a Pavel BOUCHAL

Vydání

Computional mass spectrometry-based proteomics, 2011

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

10600 1.6 Biological sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Označené pro přenos do RIV

Organizační jednotka

Přírodovědecká fakulta

Klíčová slova anglicky

proteomics, breast cancer, metastasis, biomarkers, mass spectrometry

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 12. 2011 15:34, doc. Mgr. Pavel Bouchal, Ph.D.

Anotace

V originále

The main challenge in breast cancer treatment is metastatic disease. For estimation of the risk of metastatic disease, traditional prognostic factors like tumor size, tumor grade or lymph node status are currently used. However, the predictive value of these factors is not sufficient. Therefore there is an urgent need for new more reliable molecular markers with higher sensitivity and selectivity. This project is focused on identification and functional studies on proteins involved in low-grade breast cancer metastasis. For the discovery phase we use a combination of comparative proteomics methods with validation by qRT-PCR profiling at transcript level. On the basis of our preliminary results transgelin seems to be an interesting target for further functional studies. Altered expression of transgelin has been previously reported in various types of cancers, sometimes with controversial outputs and interpretation. Here we focus on its role in breast cancer metastasis. Our preliminary data suggest that transgelin should positively influence metastasis of the tumors by increasing the migratory properties of cells through its stabilizing role on their actin cytoskeleton.

Návaznosti

GAP304/10/0868, projekt VaV

Název: Studium molekulárních mechanismů časného metastazování do lymfatických uzlin u karcinomu prsu nízkého stupně malignity pomocí proteomických technik

Investor: Grantová agentura ČR, Studium molekulárních mechanismů časného metastazování do lymfatických uzlin u karcinomu prsu nízkého stupně malignity pomocí proteomických technik

Citovat

DVOŘÁKOVÁ, Monika; Petr MÜLLER; Lenka HERNYCHOVÁ; Spiros D. GARBIS; Rudolf NENUTIL; Bořivoj VOJTĚŠEK a Pavel BOUCHAL. Identification and functional studies on proteins involved in in low-grade breast cancer metastasis. In Computional mass spectrometry-based proteomics. 2011.

@proceedings{960198,
   author = {Dvořáková, Monika and Müller, Petr and Hernychová, Lenka and Garbis, Spiros D. and Nenutil, Rudolf and Vojtěšek, Bořivoj and Bouchal, Pavel},
   booktitle = {Computional mass spectrometry-based proteomics},
   keywords = {proteomics, breast cancer, metastasis, biomarkers, mass spectrometry},
   language = {eng},
   title = {Identification and functional studies on proteins involved in in low-grade breast cancer metastasis},
   year = {2011}
}

TY  - CONF
ID  - 960198
AU  - Dvořáková, Monika - Müller, Petr - Hernychová, Lenka - Garbis, Spiros D. - Nenutil, Rudolf - Vojtěšek, Bořivoj - Bouchal, Pavel
PY  - 2011
TI  - Identification and functional studies on proteins involved in in low-grade breast cancer metastasis
KW  - proteomics, breast cancer, metastasis, biomarkers, mass spectrometry
N2  - The main challenge in breast cancer treatment is metastatic disease. For estimation of the risk of metastatic disease, traditional prognostic factors like tumor size, tumor grade or lymph node status are currently used. However, the predictive value of these factors is not sufficient. Therefore there is an urgent need for new more reliable molecular markers with higher sensitivity and selectivity. This project is focused on identification and functional studies on proteins involved in low-grade breast cancer metastasis. For the discovery phase we use a combination of comparative proteomics methods with validation by qRT-PCR profiling at transcript level. On the basis of our preliminary results transgelin seems to be an interesting target for further functional studies. Altered expression of transgelin has been previously reported in various types of cancers, sometimes with controversial outputs and interpretation. Here we focus on its role in breast cancer metastasis. Our preliminary data suggest that transgelin should positively influence metastasis of the tumors by increasing the migratory properties of cells through its stabilizing role on their actin cytoskeleton.
ER  -

DVOŘÁKOVÁ, Monika; Petr MÜLLER; Lenka HERNYCHOVÁ; Spiros D. GARBIS; Rudolf NENUTIL; Bořivoj VOJTĚŠEK a Pavel BOUCHAL. Identification and functional studies on proteins involved in in low-grade breast cancer metastasis. In \textit{Computional mass spectrometry-based proteomics}. 2011.

Přehled o publikaci