Circulating Levels of Agouti-Related Peptide in Endometrial
Cancer Survivors

J 2011

Circulating Levels of Agouti-Related Peptide in Endometrial Cancer Survivors

BIENERTOVÁ VAŠKŮ, Julie, Josef TOMANDL, Petr BIENERT, Josef CHOVANEC, Zuzana DOSTÁLOVÁ et. al.

Základní údaje

Originální název

Circulating Levels of Agouti-Related Peptide in Endometrial Cancer Survivors

Autoři

BIENERTOVÁ VAŠKŮ, Julie (203 Česká republika, garant, domácí), Josef TOMANDL (203 Česká republika, domácí), Petr BIENERT (203 Česká republika), Josef CHOVANEC (203 Česká republika, domácí), Zuzana DOSTÁLOVÁ (203 Česká republika), Anna VAŠKŮ (203 Česká republika, domácí) a Dalibor VALÍK (203 Česká republika, domácí)

Vydání

World Journal of Oncology, 2011, 1920-4531

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Kanada

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/11:00054212

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4021/wjon385w

Klíčová slova anglicky

Agouti-related peptide; Cachexia; Cancer; Cancer survivors

Změněno: 6. 6. 2012 08:58, doc. RNDr. Josef Tomandl, Ph.D.

Anotace

V originále

Recently, it has been reported that central administration of agouti-related peptide (AgRP) might have protective effect against cachexia development in tumor-bearing mice. In this study, we determined whether the disease-free endometrial cancer survivors present with different plasma AgRP levels than controls and whether there was an association with the duration of the disease- free interval. The total of 53 endometrial cancer survivors was enrolled in the study along with 93 healthy control women of similar age. Fasting blood samples were obtained and AgRP plasma levels determined using ELISA-based methodology. The AgRP plasma levels were signifi cantly higher in the cases than in the controls; AgRP levels were the lowest in obese control women; on the contrary, the AgRP plasma levels were highest in non-obese cancer survivors. Moreover, we observed signifi cant differences in AgRP levels between the endometrial cancer survivors and the control subjects [p (for comparison of the cases and the controls) = 0.002]. In the regression modeling, AgRP was signifi cantly associated with the BMI as well as the case-control status, and the case-control differences in AgRP levels retained their statistical signifi cance also after adjustment for BMI. Disease-free endometrial cancer survivors who did not develop cachexia during their treatment as well as post-treatment period present with signifi cantly higher AgRP levels than the control population, independently on their BMI and menopausal status which could be indicative of the protective effect of circulating AgRP against cachexia development in endometrial cancer.

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Josef TOMANDL, Petr BIENERT, Josef CHOVANEC, Zuzana DOSTÁLOVÁ, Anna VAŠKŮ a Dalibor VALÍK. Circulating Levels of Agouti-Related Peptide in Endometrial Cancer Survivors. World Journal of Oncology. 2011, roč. 2, č. 5, s. 232-237. ISSN 1920-4531. Dostupné z: https://dx.doi.org/10.4021/wjon385w.

@article{960899,
   author = {Bienertová Vašků, Julie and Tomandl, Josef and Bienert, Petr and Chovanec, Josef and Dostálová, Zuzana and Vašků, Anna and Valík, Dalibor},
   article_number = {5},
   doi = {http://dx.doi.org/10.4021/wjon385w},
   keywords = {Agouti-related peptide; Cachexia; Cancer; Cancer survivors},
   language = {eng},
   issn = {1920-4531},
   journal = {World Journal of Oncology},
   title = {Circulating Levels of Agouti-Related Peptide in Endometrial Cancer Survivors},
   volume = {2},
   year = {2011}
}

TY  - JOUR
ID  - 960899
AU  - Bienertová Vašků, Julie - Tomandl, Josef - Bienert, Petr - Chovanec, Josef - Dostálová, Zuzana - Vašků, Anna - Valík, Dalibor
PY  - 2011
TI  - Circulating Levels of Agouti-Related Peptide in Endometrial Cancer Survivors
JF  - World Journal of Oncology
VL  - 2
IS  - 5
SP  - 232-237
EP  - 232-237
SN  - 19204531
KW  - Agouti-related peptide
KW  - Cachexia
KW  - Cancer
KW  - Cancer survivors
N2  - Recently, it has been reported that central administration of agouti-related peptide (AgRP) might have protective effect against cachexia development in tumor-bearing mice. In this study, we determined whether the disease-free endometrial cancer survivors present with different plasma AgRP levels than controls and whether there was an association with the duration of the disease- free interval. The total of 53 endometrial cancer survivors was enrolled in the study along with 93 healthy control women of similar age. Fasting blood samples were obtained and AgRP plasma levels determined using ELISA-based methodology. The AgRP plasma levels were signifi cantly higher in the cases than in the controls; AgRP levels were the lowest in obese control women; on the contrary, the AgRP plasma levels were highest in non-obese cancer survivors. Moreover, we observed signifi cant differences in AgRP levels between the endometrial cancer survivors and the control subjects [p (for comparison of the cases and the controls) = 0.002]. In the regression modeling, AgRP was signifi cantly associated with the BMI as well as the case-control status, and the case-control differences in AgRP levels retained their statistical signifi cance also after adjustment for BMI. Disease-free endometrial cancer survivors who did not develop cachexia during their treatment as well as post-treatment period present with signifi cantly higher AgRP levels than the control population, independently on their BMI and menopausal status which could be indicative of the protective effect of circulating AgRP against cachexia development in endometrial cancer.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Josef TOMANDL, Petr BIENERT, Josef CHOVANEC, Zuzana DOSTÁLOVÁ, Anna VAŠKŮ a Dalibor VALÍK. Circulating Levels of Agouti-Related Peptide in Endometrial Cancer Survivors. \textit{World Journal of Oncology}. 2011, roč.~2, č.~5, s.~232-237. ISSN~1920-4531. Dostupné z: https://dx.doi.org/10.4021/wjon385w.

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