Whole Genome Analyses of Treponemes: New Targets for Strain-
and Subspecies- Specific Molecular Diagnostics

C 2011

Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics

ŠMAJS, David; Lenka MIKALOVÁ; Darina ČEJKOVÁ; Michal STROUHAL; Marie ZOBANÍKOVÁ et al.

Základní údaje

Originální název

Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics

Autoři

ŠMAJS, David; Lenka MIKALOVÁ; Darina ČEJKOVÁ; Michal STROUHAL; Marie ZOBANÍKOVÁ; Petra POSPÍŠILOVÁ; Steven J. NORRIS a George M. WEINSTOCK

Vydání

Rijeka (Croatia), Syphilis - Recognition, Description and Diagnosis, od s. 19-34, 16 s. Infectious Diseases, 2011

Nakladatel

InTech

Další údaje

Jazyk

angličtina

Typ výsledku

Kapitola resp. kapitoly v odborné knize

Obor

10600 1.6 Biological sciences

Stát vydavatele

Chorvatsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00050208

Organizační jednotka

Lékařská fakulta

ISBN

978-953-307-554-9

Klíčová slova anglicky

genus Treponema; syphilis

Příznaky

Recenzováno

Změněno: 14. 4. 2012 00:56, Mgr. Michal Petr

Anotace

V originále

The genus Treponema comprises several human uncultivable pathogens including Treponema pallidum subspecies pallidum (TPA, the causative agent of the sexually transmitted syphilis), Treponema pallidum subspecies pertenue (TPE, causative agent of yaws), Treponema pallidum subspecies endemicum (TEN, causing endemic syphilis), and Treponema carateum causing pinta. Additionally, the rabbit pathogen Treponema paraluiscuniculi (TPC) is very similar to syphilis treponeme but is not pathogenic to humans. Other pathogenic treponemes (e.g. Treponema denticola and T. vincentii) differ from the others by having considerably larger genomes. Moreover, these treponemes can be cultivated under in vitro conditions. The infections caused by human uncultivable pathogenic treponemes can be classified according to their invasivity, from the most invasive bacterium causing venereal syphilis to Treponema carateum (pinta), which is a non- invasive spirochete causing local dermal lesions. Strains of non-venereal treponemes including Treponema pallidum subspecies pertenue and endemicum are considered moderately invasive.

Návaznosti

GA310/07/0321, projekt VaV

Název: Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

Investor: Grantová agentura ČR, Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum

MSM0021622415, záměr

Název: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Molekulární podstata buněčných a tkáňových regulací

NT11159, projekt VaV

Název: Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Investor: Ministerstvo zdravotnictví ČR, Mapování výskytu makrolidové rezistence původce syfilis v ČR a molekulární typizace jednotlivých syfilitických kmenů

Citovat

ŠMAJS, David; Lenka MIKALOVÁ; Darina ČEJKOVÁ; Michal STROUHAL; Marie ZOBANÍKOVÁ; Petra POSPÍŠILOVÁ; Steven J. NORRIS a George M. WEINSTOCK. Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics. In Syphilis - Recognition, Description and Diagnosis. Rijeka (Croatia): InTech, 2011, s. 19-34. Infectious Diseases. ISBN 978-953-307-554-9.

@inbook{961064,
   author = {Šmajs, David and Mikalová, Lenka and Čejková, Darina and Strouhal, Michal and Zobaníková, Marie and Pospíšilová, Petra and Norris, Steven J. and Weinstock, George M.},
   address = {Rijeka (Croatia)},
   booktitle = {Syphilis - Recognition, Description and Diagnosis},
   keywords = {genus Treponema; syphilis},
   language = {eng},
   location = {Rijeka (Croatia)},
   isbn = {978-953-307-554-9},
   pages = {19-34},
   publisher = {InTech},
   title = {Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics},
   url = {http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf},
   year = {2011}
}

TY  - CHAP
ID  - 961064
AU  - Šmajs, David - Mikalová, Lenka - Čejková, Darina - Strouhal, Michal - Zobaníková, Marie - Pospíšilová, Petra - Norris, Steven J. - Weinstock, George M.
PY  - 2011
TI  - Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics
VL  - Infectious Diseases
PB  - InTech
CY  - Rijeka (Croatia)
SN  - 9789533075549
KW  - genus Treponema
KW  - syphilis
UR  - http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf
L2  - http://cdn.intechopen.com/pdfs/23784/InTech-Whole_genome_analyses_of_treponemes_new_targets_for_strain_and_subspecies_specific_molecular_diagnostics.pdf
N2  - The genus Treponema comprises several human uncultivable pathogens including Treponema pallidum subspecies pallidum (TPA, the causative agent of the sexually transmitted syphilis), Treponema pallidum subspecies pertenue (TPE, causative agent of yaws), Treponema pallidum subspecies endemicum (TEN, causing endemic syphilis), and Treponema carateum causing pinta. Additionally, the rabbit pathogen Treponema paraluiscuniculi (TPC) is very similar to syphilis treponeme but is not pathogenic to humans. Other pathogenic treponemes (e.g. Treponema denticola and T. vincentii) differ from the others by having considerably larger genomes. Moreover, these treponemes can be cultivated under in vitro conditions. The infections caused by human uncultivable pathogenic treponemes can be classified according to their invasivity, from the most invasive bacterium causing venereal syphilis to Treponema carateum (pinta), which is a non- invasive spirochete causing local dermal lesions. Strains of non-venereal treponemes including Treponema pallidum subspecies pertenue and endemicum are considered moderately invasive.
ER  -

ŠMAJS, David; Lenka MIKALOVÁ; Darina ČEJKOVÁ; Michal STROUHAL; Marie ZOBANÍKOVÁ; Petra POSPÍŠILOVÁ; Steven J. NORRIS a George M. WEINSTOCK. Whole Genome Analyses of Treponemes: New Targets for Strain- and Subspecies- Specific Molecular Diagnostics. In \textit{Syphilis - Recognition, Description and Diagnosis}. Rijeka (Croatia): InTech, 2011, s.~19-34. Infectious Diseases. ISBN~978-953-307-554-9.

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