PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL, Zuzana KUNICKÁ, Miroslav MACHALA, Alois KOZUBÍK and Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. Neoplasia. Neoplasia Press, 2011, vol. 13, No 6, p. 526-536. ISSN 1522-8002. Available from: https://dx.doi.org/10.1593/neo.11182. |
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@article{966014, author = {Pernicová, Zuzana and Slábáková, Eva and Kharaishvili, Gvantsa and Bouchal, Jan and Král, Milan and Kunická, Zuzana and Machala, Miroslav and Kozubík, Alois and Souček, Karel}, article_number = {6}, doi = {http://dx.doi.org/10.1593/neo.11182}, keywords = {CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION}, language = {eng}, issn = {1522-8002}, journal = {Neoplasia}, title = {Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2}, url = {http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf}, volume = {13}, year = {2011} }
TY - JOUR ID - 966014 AU - Pernicová, Zuzana - Slábáková, Eva - Kharaishvili, Gvantsa - Bouchal, Jan - Král, Milan - Kunická, Zuzana - Machala, Miroslav - Kozubík, Alois - Souček, Karel PY - 2011 TI - Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2 JF - Neoplasia VL - 13 IS - 6 SP - 526-536 EP - 526-536 PB - Neoplasia Press SN - 15228002 KW - CELLULAR SENESCENCE KW - IN-VIVO KW - DEPRIVATION THERAPY KW - SECRETORY PHENOTYPE KW - EPITHELIAL-CELLS KW - TUMORIGENESIS KW - FIBROBLASTS KW - EXPRESSION KW - GROWTH KW - PROLIFERATION UR - http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf L2 - http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf N2 - Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells. ER -
PERNICOVÁ, Zuzana, Eva SLÁBÁKOVÁ, Gvantsa KHARAISHVILI, Jan BOUCHAL, Milan KRÁL, Zuzana KUNICKÁ, Miroslav MACHALA, Alois KOZUBÍK and Karel SOUČEK. Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2. \textit{Neoplasia}. Neoplasia Press, 2011, vol.~13, No~6, p.~526-536. ISSN~1522-8002. Available from: https://dx.doi.org/10.1593/neo.11182.
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