The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and
Hsp70 as a predictive biomarker of outcome in children with
traumatic brain injury

J 2012

The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury

ŽUREK, Jiří a Michal FEDORA

Základní údaje

Originální název

The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury

Autoři

ŽUREK, Jiří a Michal FEDORA

Vydání

Acta neurochirurgica, WIEN, SPRINGER WIEN, 2012, 0001-6268

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.546

Označené pro přenos do RIV

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1007/s00701-011-1175-2

UT WoS

000298643300016

Klíčová slova anglicky

Biomarker; Brain injury; Outcome; Children

Příznaky

Mezinárodní význam

Změněno: 19. 10. 2015 14:09, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Predicting the long-term outcome after traumatic brain injury (TBI) is an important component of treatment strategy. Despite dramatically improved emergency management of TBI and apparent clinical recovery, most patients with TBI still may have long-term central nervous system (CNS) impairment. Sixty-three patients with TBI were enrolled into the prospective study. Venous blood samples were taken at admission and every 24 h for a maximum of 6 consecutive days. Serum concentrations of the biomarkers S100B, neuron-specific enolase (NSE), GFAP, NF-H, secretagogin and Hsp70 were quantified immuno-luminometrically or by enzyme-linked immunosorbent assay. The outcome was evaluated 6 months after TBI using the Glasgow Outcome Scale (GOS) in all patients. The S100B levels in patients with worse outcome (GOS 4 or death) were already significantly higher at D0 (p < 0.001; p = 0.002). NSE levels were significantly higher in patients who died or had worse outcomes (p < 0.001; p = 0.003). Patients who had worse outcomes (GOS) or died had higher GFAP values (p < 0.001; p < 0.001), but their dynamics were similar over the same period. NF-H grew significantly faster in patients who had a worse GOS or died (p < 0.001; p = 0.001). Although further prospective study is warranted, these findings suggest that levels of biomarkers correlate with mortality and may be useful as predictors of outcome in children with TBI.

Citovat

ŽUREK, Jiří a Michal FEDORA. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury. Acta neurochirurgica. WIEN: SPRINGER WIEN, 2012, roč. 154, č. 1, s. 93-103. ISSN 0001-6268. Dostupné z: https://doi.org/10.1007/s00701-011-1175-2.

@article{966026,
   author = {Žurek, Jiří and Fedora, Michal},
   article_location = {WIEN},
   article_number = {1},
   doi = {https://doi.org/10.1007/s00701-011-1175-2},
   keywords = {Biomarker; Brain injury; Outcome; Children},
   language = {eng},
   issn = {0001-6268},
   journal = {Acta neurochirurgica},
   title = {The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury},
   volume = {154},
   year = {2012}
}

TY  - JOUR
ID  - 966026
AU  - Žurek, Jiří - Fedora, Michal
PY  - 2012
TI  - The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury
JF  - Acta neurochirurgica
VL  - 154
IS  - 1
SP  - 93-103
EP  - 93-103
PB  - SPRINGER WIEN
SN  - 00016268
KW  - Biomarker
KW  - Brain injury
KW  - Outcome
KW  - Children
N2  - Predicting the long-term outcome after traumatic brain injury (TBI) is an important component of treatment strategy. Despite dramatically improved emergency management of TBI and apparent clinical recovery, most patients with TBI still may have long-term central nervous system (CNS) impairment. Sixty-three patients with TBI were enrolled into the prospective study. Venous blood samples were taken at admission and every 24 h for a maximum of 6 consecutive days. Serum concentrations of the biomarkers S100B, neuron-specific enolase (NSE), GFAP, NF-H, secretagogin and Hsp70 were quantified immuno-luminometrically or by enzyme-linked immunosorbent assay. The outcome was evaluated 6 months after TBI using the Glasgow Outcome Scale (GOS) in all patients. The S100B levels in patients with worse outcome (GOS 4 or death) were already significantly higher at D0 (p < 0.001; p = 0.002). NSE levels were significantly higher in patients who died or had worse outcomes (p < 0.001; p = 0.003). Patients who had worse outcomes (GOS) or died had higher GFAP values (p < 0.001; p < 0.001), but their dynamics were similar over the same period. NF-H grew significantly faster in patients who had a worse GOS or died (p < 0.001; p = 0.001). Although further prospective study is warranted, these findings suggest that levels of biomarkers correlate with mortality and may be useful as predictors of outcome in children with TBI.
ER  -

ŽUREK, Jiří a Michal FEDORA. The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury. \textit{Acta neurochirurgica}. WIEN: SPRINGER WIEN, 2012, roč.~154, č.~1, s.~93-103. ISSN~0001-6268. Dostupné z: https://doi.org/10.1007/s00701-011-1175-2.

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