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@article{966700,
author = {Soška, Vladimír and Jarkovský, Jiří and Ravčuková, Barbora and Tichý, Lukáš and Fajkusová, Lenka and Freiberger, Tomáš},
article_number = {1-2},
keywords = {Cardiovascular risk; Triglycerides/HDL-cholesterol ratio; Atherogenic index of plasma; Lipoprotein particle size},
language = {eng},
issn = {0009-9120},
journal = {Clinical Biochemistry},
title = {The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia},
volume = {45},
year = {2012}
}
TY - JOUR
ID - 966700
AU - Soška, Vladimír - Jarkovský, Jiří - Ravčuková, Barbora - Tichý, Lukáš - Fajkusová, Lenka - Freiberger, Tomáš
PY - 2012
TI - The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia
JF - Clinical Biochemistry
VL - 45
IS - 1-2
SP - 96-100
EP - 96-100
SN - 00099120
KW - Cardiovascular risk
KW - Triglycerides/HDL-cholesterol ratio
KW - Atherogenic index of plasma
KW - Lipoprotein particle size
N2 - The aim of this study was to determine whether the atherogenic index of plasma (AIP=log [triglycerides/HDL-cholesterol]) differs in heterozygous familial hypercholesterolemia (FH) patients with and without a history of cardiovascular disease (CVD). Design and methods: A total of 555 FH patients with known mutations in the LDL receptor or the apolipoprotein B gene, of whom 53 had a history of CVD (CVD+ group), were retrospectively analyzed. Results: Compared to patients without CVD (CVD- group), CVD+ patients showed significantly higher fasting LDL-cholesterol, triglycerides and AIP as well as lower HDL-cholesterol. After both adjustment for age and diabetes and using analysis based on age and sex matched groups, only the increase in triglycerides and AIP in the CVD+ vs. the CVD- group remained significant. Conclusion: The results of the present study indicate that AIP, which reflects the presence of atherogenic small LDL and small HDL particles, may be connected to the risk of CVD in FH patients.
ER -
SOŠKA, Vladimír, Jiří JARKOVSKÝ, Barbora RAVČUKOVÁ, Lukáš TICHÝ, Lenka FAJKUSOVÁ a Tomáš FREIBERGER. The logarithm of the triglyceride/HDL-cholesterol ratio is related to the history of cardiovascular disease in patients with familial hypercholesterolemia. \textit{Clinical Biochemistry}. 2012, roč.~45, 1-2, s.~96-100. ISSN~0009-9120.
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