Clinical significance of the plasminogen activator system in
relation to grade of tumor and treatment response in colorectal
carcinoma patients

J 2011

Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients

HALÁMKOVÁ, Jana; Igor KISS; Zdeněk PAVLOVSKÝ; Jiří TOMÁŠEK; Jiří JARKOVSKÝ et al.

Základní údaje

Originální název

Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients

Autoři

Vydání

Neoplasma, 2011, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.440

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00055096

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.4149/neo_2011_05_377

UT WoS

000295309700003

Klíčová slova anglicky

colorectal cancer; plasminogen activator system; grade; treatment response

Příznaky

Mezinárodní význam

Změněno: 20. 4. 2012 15:16, Mgr. Michal Petr

Anotace

V originále

Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels of PAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025). We demonstrated that there exists a statistically significant relationship between the expression of PAI 2 and uPAR (p=0.031) and grade of tumor. We also confirmed a statistically significant relationship between soluble levels of PAI 1 before treatment and therapeutic response (p=0.021). In our group of patients the expression of uPA, uPAR, PAI 1 and 2 in tumor tissue in relation to response to treatment was also assessed. Our results suggest that the greater expression of these parameters in tumor tissue is linked to a worse response to therapy. In conclusion, PAS factors help as a prognostic indicators and could also act as a predictive factor in colorectal carcinoma.

Citovat

HALÁMKOVÁ, Jana; Igor KISS; Zdeněk PAVLOVSKÝ; Jiří TOMÁŠEK; Jiří JARKOVSKÝ; Zbyněk ČECH; Štěpán TUČEK; L. HANÁKOVÁ; Mojmír MOULIS; J. ZAVŘELOVÁ; M. MAN; Petr BENDA; Oldřich ROBEK; Zdeněk KALA a Miroslav PENKA. Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. Neoplasma. 2011, roč. 58, č. 5, s. 377-385. ISSN 0028-2685. Dostupné z: https://doi.org/10.4149/neo_2011_05_377.

@article{967811,
   author = {Halámková, Jana and Kiss, Igor and Pavlovský, Zdeněk and Tomášek, Jiří and Jarkovský, Jiří and Čech, Zbyněk and Tuček, Štěpán and Hanáková, L. and Moulis, Mojmír and Zavřelová, J. and Man, M. and Benda, Petr and Robek, Oldřich and Kala, Zdeněk and Penka, Miroslav},
   article_number = {5},
   doi = {https://doi.org/10.4149/neo_2011_05_377},
   keywords = {colorectal cancer; plasminogen activator system; grade; treatment response},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients},
   volume = {58},
   year = {2011}
}

TY  - JOUR
ID  - 967811
AU  - Halámková, Jana - Kiss, Igor - Pavlovský, Zdeněk - Tomášek, Jiří - Jarkovský, Jiří - Čech, Zbyněk - Tuček, Štěpán - Hanáková, L. - Moulis, Mojmír - Zavřelová, J. - Man, M. - Benda, Petr - Robek, Oldřich - Kala, Zdeněk - Penka, Miroslav
PY  - 2011
TI  - Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
JF  - Neoplasma
VL  - 58
IS  - 5
SP  - 377-385
EP  - 377-385
SN  - 00282685
KW  - colorectal cancer
KW  - plasminogen activator system
KW  - grade
KW  - treatment response
N2  - Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels of PAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025). We demonstrated that there exists a statistically significant relationship between the expression of PAI 2 and uPAR (p=0.031) and grade of tumor. We also confirmed a statistically significant relationship between soluble levels of PAI 1 before treatment and therapeutic response (p=0.021). In our group of patients the expression of uPA, uPAR, PAI 1 and 2 in tumor tissue in relation to response to treatment was also assessed. Our results suggest that the greater expression of these parameters in tumor tissue is linked to a worse response to therapy. In conclusion, PAS factors help as a prognostic indicators and could also act as a predictive factor in colorectal carcinoma.
ER  -

HALÁMKOVÁ, Jana; Igor KISS; Zdeněk PAVLOVSKÝ; Jiří TOMÁŠEK; Jiří JARKOVSKÝ; Zbyněk ČECH; Štěpán TUČEK; L. HANÁKOVÁ; Mojmír MOULIS; J. ZAVŘELOVÁ; M. MAN; Petr BENDA; Oldřich ROBEK; Zdeněk KALA a Miroslav PENKA. Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. \textit{Neoplasma}. 2011, roč.~58, č.~5, s.~377-385. ISSN~0028-2685. Dostupné z: https://doi.org/10.4149/neo\_{}2011\_{}05\_{}377.

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