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@article{968980,
author = {Šána, Jiří and Hajdúch, Marian and Michálek, Jaroslav and Vyzula, Rostislav and Slabý, Ondřej},
article_number = {8},
doi = {http://dx.doi.org/10.1111/j.1582-4934.2011.01317.x},
keywords = {glioblastoma; microRNAs; prognosis; prediction; therapeutic targets},
language = {eng},
issn = {1582-1838},
journal = {Journal of Cellular and Molecular Medicine},
title = {MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications},
volume = {15},
year = {2011}
}
TY - JOUR
ID - 968980
AU - Šána, Jiří - Hajdúch, Marian - Michálek, Jaroslav - Vyzula, Rostislav - Slabý, Ondřej
PY - 2011
TI - MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
JF - Journal of Cellular and Molecular Medicine
VL - 15
IS - 8
SP - 1636-1644
EP - 1636-1644
SN - 15821838
KW - glioblastoma
KW - microRNAs
KW - prognosis
KW - prediction
KW - therapeutic targets
N2 - MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that act as post-transcriptional regulators of gene expression. Dysregulation of these molecules has been indicated in the development of many cancers. Altered expression levels of several miRNAs were identified also in glioblastoma. It was repeatedly found that miRNAs are involved in important signalling pathways, which play roles in crucial cellular processes, such as proliferation, apoptosis, cell cycle regulation, invasion, angiogenesis and stem cell behaviour. Therefore, miRNAs represent promising therapeutic targets in glioblastoma. In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications.
ER -
ŠÁNA, Jiří, Marian HAJDÚCH, Jaroslav MICHÁLEK, Rostislav VYZULA a Ondřej SLABÝ. MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications. \textit{Journal of Cellular and Molecular Medicine}. 2011, roč.~15, č.~8, s.~1636-1644. ISSN~1582-1838. Dostupné z: https://dx.doi.org/10.1111/j.1582-4934.2011.01317.x.
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