| OLSSON, A. C., P. GUSTAVSSON, Hans KROMHOUT, Susan PETERS, Roel VERMEULEN, Irene BRUESKE, Beate PESCH, Jack SIEMIATYCKI, Javier PINTOS, Thomas BRUENING, Adrian CASSIDY, Heinz-Erich WICHMANN, Dario CONSONNI, Maria Teresa LANDI, Neil CAPORASO, Nils PLATO, Franco MERLETTI, Dario MIRABELLI, Lorenzo RICHIARDI, Karl-Heinz JOECKEL, Wolfgang AHRENS, Hermann POHLABELN, Jolanta LISSOWSKA, Neonila SZESZENIA-DABROWSKA, David ZARIDZE, Isabelle STUECKER, Simone BENHAMOU, Vladimir BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Peter RUDNAI, Eleonora FABIANOVA, Rodica Stanescu DUMITRU, Isabelle M. GROSS, Benjamin KENDZIA, Francesco FORASTIERE, Bas BUENO-DE-MESQUITA, Paul BRENNAN, Paolo BOFFETTA a Kurt STRAIF. Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. American Journal of Respiratory And Critical Care Medicine. United States: American Thoracic Society, 2011, roč. 183, č. 7, s. 941-948. ISSN 1073-449X. Dostupné z: https://dx.doi.org/10.1164/rccm.201006-0940OC. |
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@article{969171,
author = {Olsson, A. C. and Gustavsson, P. and Kromhout, Hans and Peters, Susan and Vermeulen, Roel and Brueske, Irene and Pesch, Beate and Siemiatycki, Jack and Pintos, Javier and Bruening, Thomas and Cassidy, Adrian and Wichmann, HeinzandErich and Consonni, Dario and Landi, Maria Teresa and Caporaso, Neil and Plato, Nils and Merletti, Franco and Mirabelli, Dario and Richiardi, Lorenzo and Joeckel, KarlandHeinz and Ahrens, Wolfgang and Pohlabeln, Hermann and Lissowska, Jolanta and SzeszeniaandDabrowska, Neonila and Zaridze, David and Stuecker, Isabelle and Benhamou, Simone and Bencko, Vladimir and Foretová, Lenka and Janout, Vladimir and Rudnai, Peter and Fabianova, Eleonora and Dumitru, Rodica Stanescu and Gross, Isabelle M. and Kendzia, Benjamin and Forastiere, Francesco and BuenoanddeandMesquita, Bas and Brennan, Paul and Boffetta, Paolo and Straif, Kurt},
article_location = {United States},
article_number = {7},
doi = {http://dx.doi.org/10.1164/rccm.201006-0940OC},
keywords = {epidemiologic studies; lung neoplasm; occupational exposure; vehicle emissions},
language = {eng},
issn = {1073-449X},
journal = {American Journal of Respiratory And Critical Care Medicine},
title = {Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada},
volume = {183},
year = {2011}
}
TY - JOUR
ID - 969171
AU - Olsson, A. C. - Gustavsson, P. - Kromhout, Hans - Peters, Susan - Vermeulen, Roel - Brueske, Irene - Pesch, Beate - Siemiatycki, Jack - Pintos, Javier - Bruening, Thomas - Cassidy, Adrian - Wichmann, Heinz-Erich - Consonni, Dario - Landi, Maria Teresa - Caporaso, Neil - Plato, Nils - Merletti, Franco - Mirabelli, Dario - Richiardi, Lorenzo - Joeckel, Karl-Heinz - Ahrens, Wolfgang - Pohlabeln, Hermann - Lissowska, Jolanta - Szeszenia-Dabrowska, Neonila - Zaridze, David - Stuecker, Isabelle - Benhamou, Simone - Bencko, Vladimir - Foretová, Lenka - Janout, Vladimir - Rudnai, Peter - Fabianova, Eleonora - Dumitru, Rodica Stanescu - Gross, Isabelle M. - Kendzia, Benjamin - Forastiere, Francesco - Bueno-de-Mesquita, Bas - Brennan, Paul - Boffetta, Paolo - Straif, Kurt
PY - 2011
TI - Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada
JF - American Journal of Respiratory And Critical Care Medicine
VL - 183
IS - 7
SP - 941-948
EP - 941-948
PB - American Thoracic Society
SN - 1073449X
KW - epidemiologic studies
KW - lung neoplasm
KW - occupational exposure
KW - vehicle emissions
N2 - Rationale: Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationships. Objectives: Investigate lung cancer risk associated with occupational exposure to diesel motor exhaust, while controlling for potential confounders. Methods: The SYNERGY project pooled information on lifetime work histories and tobacco smoking from 13,304 cases and 16,282 controls from 11 case-control studies conducted in Europe and Canada. A general population job exposure matrix based on ISCO-68 occupational codes, assigning no, low, or high exposure to diesel motor exhaust, was applied to determine level of exposure. Measurements and Main Results: Odds ratios of lung cancer and 95% confidence intervals were estimated by unconditional logistic regression, adjusted for age, sex, study, ever-employment in an occupation with established lung cancer risk, cigarette pack-years, and time-since-quitting smoking. Cumulative diesel exposure was associated with an increased lung cancer risk highest quartile versus unexposed (odds ratio 1.31; 95% confidence interval, 1.19-1.43), and a significant exposure-response relationship (P value <0.01). Corresponding effect estimates were similar in workers never employed in occupations with established lung cancer risk, and in women and never-smokers, although not statistically significant. Conclusions: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models and subgroup analyses.
ER -
OLSSON, A. C., P. GUSTAVSSON, Hans KROMHOUT, Susan PETERS, Roel VERMEULEN, Irene BRUESKE, Beate PESCH, Jack SIEMIATYCKI, Javier PINTOS, Thomas BRUENING, Adrian CASSIDY, Heinz-Erich WICHMANN, Dario CONSONNI, Maria Teresa LANDI, Neil CAPORASO, Nils PLATO, Franco MERLETTI, Dario MIRABELLI, Lorenzo RICHIARDI, Karl-Heinz JOECKEL, Wolfgang AHRENS, Hermann POHLABELN, Jolanta LISSOWSKA, Neonila SZESZENIA-DABROWSKA, David ZARIDZE, Isabelle STUECKER, Simone BENHAMOU, Vladimir BENCKO, Lenka FORETOVÁ, Vladimir JANOUT, Peter RUDNAI, Eleonora FABIANOVA, Rodica Stanescu DUMITRU, Isabelle M. GROSS, Benjamin KENDZIA, Francesco FORASTIERE, Bas BUENO-DE-MESQUITA, Paul BRENNAN, Paolo BOFFETTA a Kurt STRAIF. Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. \textit{American Journal of Respiratory And Critical Care Medicine}. United States: American Thoracic Society, 2011, roč.~183, č.~7, s.~941-948. ISSN~1073-449X. Dostupné z: https://dx.doi.org/10.1164/rccm.201006-0940OC.
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