Main results of the Ouabain and Adducin for Specific
Intervention on Sodium in Hypertension Trial (OASIS-HT): a
randomized placebo-controlled phase-2 dose-finding study of
rostafuroxin

J 2011

Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

STAESSEN, Jan; Lutgarde THIJS; Katarzyna STOLARZ-SKRZYPEK; A. BACCHIERI; John BARTON et al.

Základní údaje

Originální název

Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

Autoři

Vydání

Trials, University of Oxford, 2011, 1745-6215

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.496

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/11:00055577

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1186/1745-6215-12-13

UT WoS

000286896900001

Klíčová slova anglicky

Hypertension; sodium; cardiovascular disease

Příznaky

Mezinárodní význam

Změněno: 20. 4. 2012 12:29, Mgr. Michal Petr

Anotace

V originále

The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na+,K+-ATPase and mutated adducin. Rostafuroxin lowered blood pressure (BP) in some animal models and in humans.

Citovat

STAESSEN, Jan; Lutgarde THIJS; Katarzyna STOLARZ-SKRZYPEK; A. BACCHIERI; John BARTON; Ezio ESPOSITI; Peter LEEUW; Mirosław DŁUŻNIEWSKI; Nicola GLORIOSO; Andrzej JANUSZEWICZ; Paolo MANUNTA; Viktor MILYAGIN; Yuri NIKITIN; Miroslav SOUČEK; Chiara LANZANI; Lorena CITTERIO; Mario TIMIO; Andrzej TYKARSKI; P. FERRARI; G. VALENTINI; K. KAWECKA-JASZCZ a G. BIANCHI. Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin. Trials. University of Oxford, 2011, roč. 12, č. 13, s. "nestrankovano", 14 s. ISSN 1745-6215. Dostupné z: https://doi.org/10.1186/1745-6215-12-13.

@article{971306,
   author = {Staessen, Jan and Thijs, Lutgarde and StolarzandSkrzypek, Katarzyna and Bacchieri, A. and Barton, John and Espositi, Ezio and Leeuw, Peter and Dłużniewski, Mirosław and Glorioso, Nicola and Januszewicz, Andrzej and Manunta, Paolo and Milyagin, Viktor and Nikitin, Yuri and Souček, Miroslav and Lanzani, Chiara and Citterio, Lorena and Timio, Mario and Tykarski, Andrzej and Ferrari, P. and Valentini, G. and KaweckaandJaszcz, K. and Bianchi, G.},
   article_number = {13},
   doi = {https://doi.org/10.1186/1745-6215-12-13},
   keywords = {Hypertension; sodium; cardiovascular disease},
   language = {eng},
   issn = {1745-6215},
   journal = {Trials},
   title = {Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin},
   volume = {12},
   year = {2011}
}

TY  - JOUR
ID  - 971306
AU  - Staessen, Jan - Thijs, Lutgarde - Stolarz-Skrzypek, Katarzyna - Bacchieri, A. - Barton, John - Espositi, Ezio - Leeuw, Peter - Dłużniewski, Mirosław - Glorioso, Nicola - Januszewicz, Andrzej - Manunta, Paolo - Milyagin, Viktor - Nikitin, Yuri - Souček, Miroslav - Lanzani, Chiara - Citterio, Lorena - Timio, Mario - Tykarski, Andrzej - Ferrari, P. - Valentini, G. - Kawecka-Jaszcz, K. - Bianchi, G.
PY  - 2011
TI  - Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin
JF  - Trials
VL  - 12
IS  - 13
SP  - "nestrankovano"
EP  - "nestrankovano"
PB  - University of Oxford
SN  - 17456215
KW  - Hypertension
KW  - sodium
KW  - cardiovascular disease
N2  - The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na+,K+-ATPase and mutated adducin. Rostafuroxin lowered blood pressure (BP) in some animal models and in humans.
ER  -

STAESSEN, Jan; Lutgarde THIJS; Katarzyna STOLARZ-SKRZYPEK; A. BACCHIERI; John BARTON; Ezio ESPOSITI; Peter LEEUW; Mirosław DŁU$\backslash$.ZNIEWSKI; Nicola GLORIOSO; Andrzej JANUSZEWICZ; Paolo MANUNTA; Viktor MILYAGIN; Yuri NIKITIN; Miroslav SOUČEK; Chiara LANZANI; Lorena CITTERIO; Mario TIMIO; Andrzej TYKARSKI; P. FERRARI; G. VALENTINI; K. KAWECKA-JASZCZ a G. BIANCHI. Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin. \textit{Trials}. University of Oxford, 2011, roč.~12, č.~13, s.~''nestrankovano'', 14 s. ISSN~1745-6215. Dostupné z: https://doi.org/10.1186/1745-6215-12-13.

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