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@proceedings{974558,
author = {Šrámková, Zuzana and Procházková, Jiřina and Kotasová, Hana and Tmejová, Kateřina and Gudernová, Iva and Pacherník, Jiří},
booktitle = {VI. konference Analytická cytometri},
keywords = {STAT3; MDR1; enhanceosom},
language = {eng},
isbn = {978-80-260-0676-3},
title = {Localization of the STAT3 binding site in the MDR1 enhanceosom},
year = {2011}
}
TY - CONF
ID - 974558
AU - Šrámková, Zuzana - Procházková, Jiřina - Kotasová, Hana - Tmejová, Kateřina - Gudernová, Iva - Pacherník, Jiří
PY - 2011
TI - Localization of the STAT3 binding site in the MDR1 enhanceosom
SN - 9788026006763
KW - STAT3
KW - MDR1
KW - enhanceosom
N2 - The work evidenced that STAT3-induced over-expression of MDR1 is dependent on area assigned *824, so we can conclude that in this area is localized the crucial STAT3 binding site. Area *824 contains direct repeat with a three-nucleotide spacer and a three direct repeats with four-nucleotide spacer. Previous studies have shown that pregnane X receptor and constitutive androstane receptor, members of the nuclear receptor superfamily, as well as thyroid hormone receptors, mediate the up-regulation of MDR1 through this response region located -7.9 to -7.8 kb upstream of the MDR1 using an epithelial cell line LS174T or Caco2 (Burk et al., 2005; Geick et al., 2001; Kurose et al. 2008). This illustrates the general importance of this enhancer region upstream of MDR1 gene.
ER -
ŠRÁMKOVÁ, Zuzana, Jiřina PROCHÁZKOVÁ, Hana KOTASOVÁ, Kateřina TMEJOVÁ, Iva GUDERNOVÁ a Jiří PACHERNÍK. Localization of the STAT3 binding site in the MDR1 enhanceosom. In \textit{VI. konference Analytická cytometri}. 2011. ISBN~978-80-260-0676-3.
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