| STIXOVÁ, Lenka, Pavel MATULA, Stanislav KOZUBEK, Dušan CMARKO, Adriana GOMBITOVÁ, Ivan RAŠKA a Eva BÁRTOVÁ. Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency. Biology of the Cell. 2012, roč. 104, č. 7, s. 418-432. ISSN 0248-4900. Dostupné z: https://dx.doi.org/10.1111/boc.201100053. |
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@article{975303,
author = {Stixová, Lenka and Matula, Pavel and Kozubek, Stanislav and Cmarko, Dušan and Gombitová, Adriana and Raška, Ivan and Bártová, Eva},
article_number = {7},
doi = {http://dx.doi.org/10.1111/boc.201100053},
keywords = {ACUTE PROMYELOCYTIC LEUKEMIA; DOUBLE-STRAND BREAKS; HUMAN-CELLS; PROTEIN STRUCTURES; STEM-CELLS; RAR-ALPHA; RNA; TELOMERE; HETEROCHROMATIN; TRANSCRIPTION},
language = {eng},
issn = {0248-4900},
journal = {Biology of the Cell},
title = {Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency},
url = {http://onlinelibrary.wiley.com/doi/10.1111/boc.201100053/abstract},
volume = {104},
year = {2012}
}
TY - JOUR
ID - 975303
AU - Stixová, Lenka - Matula, Pavel - Kozubek, Stanislav - Cmarko, Dušan - Gombitová, Adriana - Raška, Ivan - Bártová, Eva
PY - 2012
TI - Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency
JF - Biology of the Cell
VL - 104
IS - 7
SP - 418-432
EP - 418-432
SN - 02484900
KW - ACUTE PROMYELOCYTIC LEUKEMIA
KW - DOUBLE-STRAND BREAKS
KW - HUMAN-CELLS
KW - PROTEIN STRUCTURES
KW - STEM-CELLS
KW - RAR-ALPHA
KW - RNA
KW - TELOMERE
KW - HETEROCHROMATIN
KW - TRANSCRIPTION
UR - http://onlinelibrary.wiley.com/doi/10.1111/boc.201100053/abstract
L2 - http://onlinelibrary.wiley.com/doi/10.1111/boc.201100053/abstract
N2 - Background information Promyelocytic leukaemia (PML) bodies are specific nuclear structures with functional significance for acute promyelocytic leukaemia. In this study, we analysed the trajectories of PML bodies using single-particle tracking. Results We observed that the recovery of PML protein after photobleaching was ATP dependent in both wild-type (wt) and A-type lamin-deficient cells. The movement of PML bodies was faster and the nuclear area occupied by particular PML bodies was larger in A-type lamin-deficient fibroblasts compared with their wt counterparts. Moreover, dysfunction of the LMNA gene increased the frequency of mutual interactions between individual PML bodies and influenced the morphology of these domains at the ultrastructural level. As a consequence of A-type lamin deficiency, PML protein accumulated in nuclear blebs and frequently appeared at the nuclear periphery. Conclusions We suggest that the physiological function of lamin A proteins is important for events that occur in the compartment of PML bodies. This observation was confirmed in other experimental models characterised by lamin changes, including apoptosis or the differentiation of mouse embryonic stem cells.
ER -
STIXOVÁ, Lenka, Pavel MATULA, Stanislav KOZUBEK, Dušan CMARKO, Adriana GOMBITOVÁ, Ivan RAŠKA a Eva BÁRTOVÁ. Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency. \textit{Biology of the Cell}. 2012, roč.~104, č.~7, s.~418-432. ISSN~0248-4900. Dostupné z: https://dx.doi.org/10.1111/boc.201100053.
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