Prognostic significance of low volume sentinel lymph node
disease in early-stage cervical cancer

J 2012

Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer

CIBULA, D., R.D. ABU-RUSTUM, Ladislav DUŠEK, M. ZIKÁN, A. ZAAL et. al.

Základní údaje

Originální název

Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer

Autoři

CIBULA, D. (203 Česká republika, garant), R.D. ABU-RUSTUM (840 Spojené státy), Ladislav DUŠEK (203 Česká republika, domácí), M. ZIKÁN (203 Česká republika), A. ZAAL (528 Nizozemské království), L. SEVCIK (203 Česká republika), G.G. KENTER (528 Nizozemské království), D. QUERLEU (250 Francie), R. JACH (616 Polsko), A.S. BATS (250 Francie), G. DYDUCH (616 Polsko), P. GRAF (203 Česká republika), J. KLAT (203 Česká republika), J. LACHETA (203 Česká republika), C.J.L.M. MEIJER (528 Nizozemské království), E. MERY (250 Francie), R. VERHEIJEN (528 Nizozemské království) a R.P. ZWEEMER (528 Nizozemské království)

Vydání

Gynecologic Oncology, 2012, 0090-8258

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.929

Kód RIV

RIV/00216224:14110/12:00059783

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ygyno.2011.11.037

UT WoS

000300751900021

Klíčová slova anglicky

Cervical cancer; Sentinel node; Micrometastasis; Isolated tumor cells; Low volume disease

Příznaky

Mezinárodní význam

Změněno: 26. 4. 2012 10:01, Mgr. Michal Petr

Anotace

V originále

Evaluate prognostic significance of low volume disease detected in sentinel nodes (SN) of patients with early stages cervical cancer. Although pathologic ultrastaging of SN allows for identification of low volume disease, including micro-metastasis and isolated tumor cells (ITC), in up to 15% of cases, prognostic significance of these findings is unknown. Methods: A total of 645 records from 8 centers were retrospectively reviewed. Enrolled in our study were patients with early-stage cervical cancer who had undergone surgical treatment including SN biopsy followed by pelvic lymphadenectomy and pathologic ultrastaging of SN. Results: Macrometastasis, micrometastasis, and ITC were detected by SN ultrastaging in 14.7%, 10.1%, and 4.5% patients respectively. False negativity of SN ultrastaging reached 2.8%. The presence of ITC was not associated with significant risk, both for recurrence free survival and overall survival. Overall survival was significantly reduced in patients with macrometastasis and micrometastasis; hazard ratio for overall survival reached 6.85 (95% CI, 2.59–18.05) and 6.86 (95% CI, 2.09–22.61) respectively. Presence of micrometastasis was an independent prognostic factor for overall survival in a multivariable model. Conclusion: Presence of micrometastasis in SN in patients with early stage cervical cancer was associated with significant reduction of overall survival, which was equivalent to patients with macrometastasis. No prognostic significance was found for ITC. These data highlight the importance of SN biopsy and pathologic ultrastaging for the management of cervical cancer.

Citovat

CIBULA, D., R.D. ABU-RUSTUM, Ladislav DUŠEK, M. ZIKÁN, A. ZAAL, L. SEVCIK, G.G. KENTER, D. QUERLEU, R. JACH, A.S. BATS, G. DYDUCH, P. GRAF, J. KLAT, J. LACHETA, C.J.L.M. MEIJER, E. MERY, R. VERHEIJEN a R.P. ZWEEMER. Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. Gynecologic Oncology. 2012, roč. 124, č. 3, s. 496–501. ISSN 0090-8258. Dostupné z: https://dx.doi.org/10.1016/j.ygyno.2011.11.037.

@article{980517,
   author = {Cibula, D. and AbuandRustum, R.D. and Dušek, Ladislav and Zikán, M. and Zaal, A. and Sevcik, L. and Kenter, G.G. and Querleu, D. and Jach, R. and Bats, A.S. and Dyduch, G. and Graf, P. and Klat, J. and Lacheta, J. and Meijer, C.J.L.M. and Mery, E. and Verheijen, R. and Zweemer, R.P.},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.ygyno.2011.11.037},
   keywords = {Cervical cancer; Sentinel node; Micrometastasis; Isolated tumor cells; Low volume disease},
   language = {eng},
   issn = {0090-8258},
   journal = {Gynecologic Oncology},
   title = {Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer},
   volume = {124},
   year = {2012}
}

TY  - JOUR
ID  - 980517
AU  - Cibula, D. - Abu-Rustum, R.D. - Dušek, Ladislav - Zikán, M. - Zaal, A. - Sevcik, L. - Kenter, G.G. - Querleu, D. - Jach, R. - Bats, A.S. - Dyduch, G. - Graf, P. - Klat, J. - Lacheta, J. - Meijer, C.J.L.M. - Mery, E. - Verheijen, R. - Zweemer, R.P.
PY  - 2012
TI  - Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer
JF  - Gynecologic Oncology
VL  - 124
IS  - 3
SP  - 496–501
EP  - 496–501
SN  - 00908258
KW  - Cervical cancer
KW  - Sentinel node
KW  - Micrometastasis
KW  - Isolated tumor cells
KW  - Low volume disease
N2  - Evaluate prognostic significance of low volume disease detected in sentinel nodes (SN) of patients with early stages cervical cancer. Although pathologic ultrastaging of SN allows for identification of low volume disease, including micro-metastasis and isolated tumor cells (ITC), in up to 15% of cases, prognostic significance of these findings is unknown. Methods: A total of 645 records from 8 centers were retrospectively reviewed. Enrolled in our study were patients with early-stage cervical cancer who had undergone surgical treatment including SN biopsy followed by pelvic lymphadenectomy and pathologic ultrastaging of SN. Results: Macrometastasis, micrometastasis, and ITC were detected by SN ultrastaging in 14.7%, 10.1%, and 4.5% patients respectively. False negativity of SN ultrastaging reached 2.8%. The presence of ITC was not associated with significant risk, both for recurrence free survival and overall survival. Overall survival was significantly reduced in patients with macrometastasis and micrometastasis; hazard ratio for overall survival reached 6.85 (95% CI, 2.59–18.05) and 6.86 (95% CI, 2.09–22.61) respectively. Presence of micrometastasis was an independent prognostic factor for overall survival in a multivariable model. Conclusion: Presence of micrometastasis in SN in patients with early stage cervical cancer was associated with significant reduction of overall survival, which was equivalent to patients with macrometastasis. No prognostic significance was found for ITC. These data highlight the importance of SN biopsy and pathologic ultrastaging for the management of cervical cancer.
ER  -

CIBULA, D., R.D. ABU-RUSTUM, Ladislav DUŠEK, M. ZIKÁN, A. ZAAL, L. SEVCIK, G.G. KENTER, D. QUERLEU, R. JACH, A.S. BATS, G. DYDUCH, P. GRAF, J. KLAT, J. LACHETA, C.J.L.M. MEIJER, E. MERY, R. VERHEIJEN a R.P. ZWEEMER. Prognostic significance of low volume sentinel lymph node disease in early-stage cervical cancer. \textit{Gynecologic Oncology}. 2012, roč.~124, č.~3, s.~496–501. ISSN~0090-8258. Dostupné z: https://dx.doi.org/10.1016/j.ygyno.2011.11.037.

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