Genomic analysis of resistance/susceptibility to melanoma in
Old Kladruber greying horses

J 2012

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

FUTAS, J.; L. VYCHODILOVA; B. HOFMANOVA; M. VRANOVA; L. PUTNOVA et al.

Základní údaje

Originální název

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Autoři

FUTAS, J.; L. VYCHODILOVA; B. HOFMANOVA; M. VRANOVA; L. PUTNOVA; Jan MUŽÍK; M. VYSKOCIL; I. VRTKOVA; Ladislav DUŠEK; I. MAJZLIK a P. HORIN

Vydání

Tissue Antigens, 2012, 0001-2815

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

Genetika a molekulární biologie

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.753

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/12:00059784

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1111/j.1399-0039.2011.01827.x

UT WoS

000300978800003

Klíčová slova anglicky

association analysis; greying horse; melanoma; microsatellites; single nucleotide polymorphisms

Příznaky

Mezinárodní význam

Změněno: 26. 4. 2012 10:08, Mgr. Michal Petr

Anotace

V originále

Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless of the breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely the variation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzing associations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.

Citovat

FUTAS, J.; L. VYCHODILOVA; B. HOFMANOVA; M. VRANOVA; L. PUTNOVA; Jan MUŽÍK; M. VYSKOCIL; I. VRTKOVA; Ladislav DUŠEK; I. MAJZLIK a P. HORIN. Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses. Tissue Antigens. 2012, roč. 79, č. 4, s. 247-248. ISSN 0001-2815. Dostupné z: https://doi.org/10.1111/j.1399-0039.2011.01827.x.

@article{980519,
   author = {Futas, J. and Vychodilova, L. and Hofmanova, B. and Vranova, M. and Putnova, L. and Mužík, Jan and Vyskocil, M. and Vrtkova, I. and Dušek, Ladislav and Majzlik, I. and Horin, P.},
   article_number = {4},
   doi = {https://doi.org/10.1111/j.1399-0039.2011.01827.x},
   keywords = {association analysis; greying horse; melanoma; microsatellites; single nucleotide polymorphisms},
   language = {eng},
   issn = {0001-2815},
   journal = {Tissue Antigens},
   title = {Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses},
   volume = {79},
   year = {2012}
}

TY  - JOUR
ID  - 980519
AU  - Futas, J. - Vychodilova, L. - Hofmanova, B. - Vranova, M. - Putnova, L. - Mužík, Jan - Vyskocil, M. - Vrtkova, I. - Dušek, Ladislav - Majzlik, I. - Horin, P.
PY  - 2012
TI  - Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses
JF  - Tissue Antigens
VL  - 79
IS  - 4
SP  - 247-248
EP  - 247-248
SN  - 00012815
KW  - association analysis
KW  - greying horse
KW  - melanoma
KW  - microsatellites
KW  - single nucleotide polymorphisms
N2  - Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless of the breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely the variation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzing associations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.
ER  -

FUTAS, J.; L. VYCHODILOVA; B. HOFMANOVA; M. VRANOVA; L. PUTNOVA; Jan MUŽÍK; M. VYSKOCIL; I. VRTKOVA; Ladislav DUŠEK; I. MAJZLIK a P. HORIN. Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses. \textit{Tissue Antigens}. 2012, roč.~79, č.~4, s.~247-248. ISSN~0001-2815. Dostupné z: https://doi.org/10.1111/j.1399-0039.2011.01827.x.

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