MicroRNA-650 expression is influenced by immunoglobulin gene
rearrangement and affects the biology of chronic lymphocytic
leukemia

J 2012

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

MRÁZ, Marek; Dáša DOLEŽALOVÁ; Karla PLEVOVÁ; Kateřina STAŇO KOZUBÍK; Veronika MAYEROVÁ et. al.

Základní údaje

Originální název

MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia

Vydání

Blood, WASHINGTON, Amer Soc Hematology, 2012, 0006-4971

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.060

Kód RIV

RIV/00216224:14740/12:00059794

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1182/blood-2011-11-394874

UT WoS

000300949500022

Klíčová slova anglicky

CLL PATIENTS; SURVIVAL; SUBTYPES

Štítky

ok, rivok

Příznaky

Mezinárodní význam

Změněno: 11. 4. 2013 13:02, Olga Křížová

Anotace

V originále

MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. Notably, miRNA gene encoding miR-650 and its homologs overlap with several variable (V) subgenes coding for lambda immunoglobulin (IgL lambda). Recent studies describe the role of miR-650 in solid tumors, but its role in chronic lymphocytic leukemia (CLL) has not yet been studied. Our experiments demonstrate that miR-650 expression is regulated by coupled expression with its host gene for IgL lambda. This coupling provides a unique yet unobserved mechanism for microRNA gene regulation. We determine that higher expression of miR-650 is associated with a favorable CLL prognosis and influences the proliferation capacity of B cells. We also establish that in B cells, miR-650 targets proteins important in cell proliferation and survival: cyclin dependent kinase 1 (CDK1), inhibitor of growth 4 (ING4), and early B-cell factor 3 (EBF3). This study underscores the importance of miR-650 in CLL biology and normal B-cell physiology.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622430, záměr

Název: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

NT11218, projekt VaV

Název: Funkční a strukturní změny microRNA u lymfoproliferativních malignit a jejich vliv na prognózu onemocnění a predikci léčebné odpovědi

Citovat

MRÁZ, Marek; Dáša DOLEŽALOVÁ; Karla PLEVOVÁ; Kateřina STAŇO KOZUBÍK; Veronika MAYEROVÁ; Kateřina ČERNÁ; Kateřina MUSILOVÁ; Boris TICHÝ; Šárka PAVLOVÁ; Marek BORSKÝ; Jan VERNER; Michael DOUBEK; Yvona BRYCHTOVÁ; Martin TRBUŠEK; Aleš HAMPL; Jiří MAYER a Šárka POSPÍŠILOVÁ. MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. Blood. WASHINGTON: Amer Soc Hematology, 2012, roč. 119, č. 9, s. 2110-2113. ISSN 0006-4971. Dostupné z: https://doi.org/10.1182/blood-2011-11-394874.

@article{980555,
   author = {Mráz, Marek and Doležalová, Dáša and Plevová, Karla and Staňo Kozubík, Kateřina and Mayerová, Veronika and Černá, Kateřina and Musilová, Kateřina and Tichý, Boris and Pavlová, Šárka and Borský, Marek and Verner, Jan and Doubek, Michael and Brychtová, Yvona and Trbušek, Martin and Hampl, Aleš and Mayer, Jiří and Pospíšilová, Šárka},
   article_location = {WASHINGTON},
   article_number = {9},
   doi = {https://doi.org/10.1182/blood-2011-11-394874},
   keywords = {CLL PATIENTS; SURVIVAL; SUBTYPES},
   language = {eng},
   issn = {0006-4971},
   journal = {Blood},
   title = {MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia},
   url = {http://bloodjournal.hematologylibrary.org/content/119/9/2110},
   volume = {119},
   year = {2012}
}

TY  - JOUR
ID  - 980555
AU  - Mráz, Marek - Doležalová, Dáša - Plevová, Karla - Staňo Kozubík, Kateřina - Mayerová, Veronika - Černá, Kateřina - Musilová, Kateřina - Tichý, Boris - Pavlová, Šárka - Borský, Marek - Verner, Jan - Doubek, Michael - Brychtová, Yvona - Trbušek, Martin - Hampl, Aleš - Mayer, Jiří - Pospíšilová, Šárka
PY  - 2012
TI  - MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia
JF  - Blood
VL  - 119
IS  - 9
SP  - 2110-2113
EP  - 2110-2113
PB  - Amer Soc Hematology
SN  - 00064971
KW  - CLL PATIENTS
KW  - SURVIVAL
KW  - SUBTYPES
UR  - http://bloodjournal.hematologylibrary.org/content/119/9/2110
L2  - http://bloodjournal.hematologylibrary.org/content/119/9/2110
N2  - MicroRNAs (miRNAs) play a key role in chronic lymphocytic leukemia as well as in normal B cells. Notably, miRNA gene encoding miR-650 and its homologs overlap with several variable (V) subgenes coding for lambda immunoglobulin (IgL lambda). Recent studies describe the role of miR-650 in solid tumors, but its role in chronic lymphocytic leukemia (CLL) has not yet been studied. Our experiments demonstrate that miR-650 expression is regulated by coupled expression with its host gene for IgL lambda. This coupling provides a unique yet unobserved mechanism for microRNA gene regulation. We determine that higher expression of miR-650 is associated with a favorable CLL prognosis and influences the proliferation capacity of B cells. We also establish that in B cells, miR-650 targets proteins important in cell proliferation and survival: cyclin dependent kinase 1 (CDK1), inhibitor of growth 4 (ING4), and early B-cell factor 3 (EBF3). This study underscores the importance of miR-650 in CLL biology and normal B-cell physiology.
ER  -

MRÁZ, Marek; Dáša DOLEŽALOVÁ; Karla PLEVOVÁ; Kateřina STAŇO KOZUBÍK; Veronika MAYEROVÁ; Kateřina ČERNÁ; Kateřina MUSILOVÁ; Boris TICHÝ; Šárka PAVLOVÁ; Marek BORSKÝ; Jan VERNER; Michael DOUBEK; Yvona BRYCHTOVÁ; Martin TRBUŠEK; Aleš HAMPL; Jiří MAYER a Šárka POSPÍŠILOVÁ. MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. \textit{Blood}. WASHINGTON: Amer Soc Hematology, 2012, roč.~119, č.~9, s.~2110-2113. ISSN~0006-4971. Dostupné z: https://doi.org/10.1182/blood-2011-11-394874.

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