Subject-specific profiles of QT/RR hysteresis

J 2008

Subject-specific profiles of QT/RR hysteresis

MALIK, Marek; Kateřina HNATKOVA; Tomáš NOVOTNÝ a G. SCHMIDT

Základní údaje

Originální název

Subject-specific profiles of QT/RR hysteresis

Autoři

MALIK, Marek; Kateřina HNATKOVA; Tomáš NOVOTNÝ a G. SCHMIDT

Vydání

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 0363-6135

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.643

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/08:00059842

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1152/ajpheart.00625.2008

UT WoS

000261399900018

Klíčová slova anglicky

QT adaptation; individual QT correction; electrocardiogram measurement; corrected QT variability

Příznaky

Mezinárodní význam

Změněno: 4. 5. 2012 14:26, Mgr. Michal Petr

Anotace

V originále

The time lag of the QT interval adaptation to heart rate changes (QT/RR hysteresis) was studied in 40 healthy subjects (18 females; mean age, 30.4 +/- 8.1 yr) with 3 separate daytime (> 13 h) 12-lead electrocardiograms (ECG) in each subject. In each recording, 330 individual 10-s ECG segments were measured, including 100 segments preceded by 2 min of heart rate varying greater than +/- 2 beats/min. Other segments were preceded by a stable heart rate. In segments preceded by variable rate, QT/RR hysteresis was characterized by lambda parameters of the exponential decay models. The intrasubject SDs of lambda values were compared with the intersubject SD of the individual means. The lambda values were also correlated to individually optimized parameters of heart rate correction. Intrasubject SDs of lambda were substantially smaller than the population SD of individual means (0.390 +/- 0.197 vs. 0.711, P < 0.0001). The lambda values were unrelated to the QT/RR correction parameters. When compared with the corrected QT (QTc) for averaged RR intervals in 10-s ECGs and with the averaged RR intervals in 2-min history, QTc for QT/RR hysteresis led to a substantially smaller SD of QTc values (11.4 +/- 2.00, 6.33 +/- 1.31, and 4.66 +/- 0.85 ms, respectively, P < 0.0001). Thus the speed with which the QT interval adapts to heart rate changes is highly individual with intrasubject stability and intersubject variability. QT/RR hysteresis is independent of the static QT/RR relationship and should be considered as a separate physiological process. The combination of individual heart rate correction with individual hysteresis correction of the QT interval is likely to lead to substantial improvements of cardiac repolarization studies.

Citovat

MALIK, Marek; Kateřina HNATKOVA; Tomáš NOVOTNÝ a G. SCHMIDT. Subject-specific profiles of QT/RR hysteresis. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2008, roč. 295, č. 6, s. "H2356"-"H2363", 8 s. ISSN 0363-6135. Dostupné z: https://doi.org/10.1152/ajpheart.00625.2008.

@article{981064,
   author = {Malik, Marek and Hnatkova, Kateřina and Novotný, Tomáš and Schmidt, G.},
   article_number = {6},
   doi = {https://doi.org/10.1152/ajpheart.00625.2008},
   keywords = {QT adaptation; individual QT correction; electrocardiogram measurement; corrected QT variability},
   language = {eng},
   issn = {0363-6135},
   journal = {AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY},
   title = {Subject-specific profiles of QT/RR hysteresis},
   volume = {295},
   year = {2008}
}

TY  - JOUR
ID  - 981064
AU  - Malik, Marek - Hnatkova, Kateřina - Novotný, Tomáš - Schmidt, G.
PY  - 2008
TI  - Subject-specific profiles of QT/RR hysteresis
JF  - AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
VL  - 295
IS  - 6
SP  - "H2356"-"H2363"
EP  - "H2356"-"H2363"
SN  - 03636135
KW  - QT adaptation
KW  - individual QT correction
KW  - electrocardiogram measurement
KW  - corrected QT variability
N2  - The time lag of the QT interval adaptation to heart rate changes (QT/RR hysteresis) was studied in 40 healthy subjects (18 females; mean age, 30.4 +/- 8.1 yr) with 3 separate daytime (> 13 h) 12-lead electrocardiograms (ECG) in each subject. In each recording, 330 individual 10-s ECG segments were measured, including 100 segments preceded by 2 min of heart rate varying greater than +/- 2 beats/min. Other segments were preceded by a stable heart rate. In segments preceded by variable rate, QT/RR hysteresis was characterized by lambda parameters of the exponential decay models. The intrasubject SDs of lambda values were compared with the intersubject SD of the individual means. The lambda values were also correlated to individually optimized parameters of heart rate correction. Intrasubject SDs of lambda were substantially smaller than the population SD of individual means (0.390 +/- 0.197 vs. 0.711, P < 0.0001). The lambda values were unrelated to the QT/RR correction parameters. When compared with the corrected QT (QTc) for averaged RR intervals in 10-s ECGs and with the averaged RR intervals in 2-min history, QTc for QT/RR hysteresis led to a substantially smaller SD of QTc values (11.4 +/- 2.00, 6.33 +/- 1.31, and 4.66 +/- 0.85 ms, respectively, P < 0.0001). Thus the speed with which the QT interval adapts to heart rate changes is highly individual with intrasubject stability and intersubject variability. QT/RR hysteresis is independent of the static QT/RR relationship and should be considered as a separate physiological process. The combination of individual heart rate correction with individual hysteresis correction of the QT interval is likely to lead to substantial improvements of cardiac repolarization studies.
ER  -

MALIK, Marek; Kateřina HNATKOVA; Tomáš NOVOTNÝ a G. SCHMIDT. Subject-specific profiles of QT/RR hysteresis. \textit{AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY}. 2008, roč.~295, č.~6, s.~''H2356''-''H2363'', 8 s. ISSN~0363-6135. Dostupné z: https://doi.org/10.1152/ajpheart.00625.2008.

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