New role for L-arginine in regulation of inducible
nitric-oxide-synthase-derived superoxide anion production in
raw 264.7 macrophages.

J 2011

New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.

PEKAROVÁ, Michaela; Antonín LOJEK; Hana MARTIŠKOVÁ; Ondřej VAŠÍČEK; Lucia BINÓ et al.

Základní údaje

Originální název

New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.

Autoři

PEKAROVÁ, Michaela; Antonín LOJEK; Hana MARTIŠKOVÁ; Ondřej VAŠÍČEK; Lucia BINÓ; Anna KLINKE; Denise LAU; Radek KUCHTA; Jaroslav KADLEC; Radimír VRBA a Lukáš KUBALA

Vydání

The Scientific World Journal, NY, USA, 2011, 1537-744X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.524 v roce 2010

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/11:00081807

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1100/2011/321979

UT WoS

000298416400011

Klíčová slova anglicky

Macrophages; L-arginine; inducible nitric oxide synthase; superoxide anion; NO

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 4. 2016 08:02, Ing. Andrea Mikešková

Anotace

V originále

Dietary supplementation with L-arginine was shown to improve immune responses in various inflammatory models. However, the molecular mechanisms underlying L-arginine effects on immune cells remain unrecognized. Herein, we tested the hypothesis that a limitation of L-arginine could lead to the uncoupled state of murine macrophage inducible nitric oxide synthase and, therefore, increase inducible nitric-oxide-synthase-derived superoxide anion formation. Importantly, we demonstrated that L-arginine dose- and time dependently potentiated superoxide anion production in bacterial endotoxin-stimulated macrophages, although it did not influence NADPH oxidase expression and activity.

Citovat

PEKAROVÁ, Michaela; Antonín LOJEK; Hana MARTIŠKOVÁ; Ondřej VAŠÍČEK; Lucia BINÓ; Anna KLINKE; Denise LAU; Radek KUCHTA; Jaroslav KADLEC; Radimír VRBA a Lukáš KUBALA. New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages. The Scientific World Journal. NY, USA, 2011, roč. 11, č. 11, s. 2443-2457. ISSN 1537-744X. Dostupné z: https://doi.org/10.1100/2011/321979.

@article{983204,
   author = {Pekarová, Michaela and Lojek, Antonín and Martišková, Hana and Vašíček, Ondřej and Binó, Lucia and Klinke, Anna and Lau, Denise and Kuchta, Radek and Kadlec, Jaroslav and Vrba, Radimír and Kubala, Lukáš},
   article_location = {NY, USA},
   article_number = {11},
   doi = {https://doi.org/10.1100/2011/321979},
   keywords = {Macrophages; L-arginine; inducible nitric oxide synthase; superoxide anion; NO},
   language = {eng},
   issn = {1537-744X},
   journal = {The Scientific World Journal},
   title = {New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.},
   url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246759/?tool=pubmed},
   volume = {11},
   year = {2011}
}

TY  - JOUR
ID  - 983204
AU  - Pekarová, Michaela - Lojek, Antonín - Martišková, Hana - Vašíček, Ondřej - Binó, Lucia - Klinke, Anna - Lau, Denise - Kuchta, Radek - Kadlec, Jaroslav - Vrba, Radimír - Kubala, Lukáš
PY  - 2011
TI  - New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages.
JF  - The Scientific World Journal
VL  - 11
IS  - 11
SP  - 2443-2457
EP  - 2443-2457
SN  - 1537744X
KW  - Macrophages
KW  - L-arginine
KW  - inducible nitric oxide synthase
KW  - superoxide anion
KW  - NO
UR  - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246759/?tool=pubmed
N2  - Dietary supplementation with L-arginine was shown to improve immune responses in various inflammatory models. However, the molecular mechanisms underlying L-arginine effects on immune cells remain unrecognized. Herein, we tested the hypothesis that a limitation of L-arginine could lead to the uncoupled state of murine macrophage inducible nitric oxide synthase and, therefore, increase inducible nitric-oxide-synthase-derived superoxide anion formation. Importantly, we demonstrated that L-arginine dose- and time dependently potentiated superoxide anion production in bacterial endotoxin-stimulated macrophages, although it did not influence NADPH oxidase expression and activity.
ER  -

PEKAROVÁ, Michaela; Antonín LOJEK; Hana MARTIŠKOVÁ; Ondřej VAŠÍČEK; Lucia BINÓ; Anna KLINKE; Denise LAU; Radek KUCHTA; Jaroslav KADLEC; Radimír VRBA a Lukáš KUBALA. New role for L-arginine in regulation of inducible nitric-oxide-synthase-derived superoxide anion production in raw 264.7 macrophages. \textit{The Scientific World Journal}. NY, USA, 2011, roč.~11, č.~11, s.~2443-2457. ISSN~1537-744X. Dostupné z: https://doi.org/10.1100/2011/321979.

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