| ŠÁNA, Jiří, Petra FALTEJSKOVÁ, Marek SVOBODA a Ondřej SLABÝ. Novel classes of non-coding RNAs and cancer. Journal of Translational Medicine. London, England: BIOMED CENTRAL LTD, 2012, roč. 10, May, s. "nestránkováno", 21 s. ISSN 1479-5876. Dostupné z: https://dx.doi.org/10.1186/1479-5876-10-103. |
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@article{983319,
author = {Šána, Jiří and Faltejsková, Petra and Svoboda, Marek and Slabý, Ondřej},
article_location = {London, England},
article_number = {May},
doi = {http://dx.doi.org/10.1186/1479-5876-10-103},
keywords = {non-coding RNAs; microRNAs; siRNAs; piRNAs; lncRNAs; cancer},
language = {eng},
issn = {1479-5876},
journal = {Journal of Translational Medicine},
title = {Novel classes of non-coding RNAs and cancer},
url = {http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf},
volume = {10},
year = {2012}
}
TY - JOUR
ID - 983319
AU - Šána, Jiří - Faltejsková, Petra - Svoboda, Marek - Slabý, Ondřej
PY - 2012
TI - Novel classes of non-coding RNAs and cancer
JF - Journal of Translational Medicine
VL - 10
IS - May
SP - "nestránkováno"
EP - "nestránkováno"
PB - BIOMED CENTRAL LTD
SN - 14795876
KW - non-coding RNAs
KW - microRNAs
KW - siRNAs
KW - piRNAs
KW - lncRNAs
KW - cancer
UR - http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf
L2 - http://www.translational-medicine.com/content/pdf/1479-5876-10-103.pdf
N2 - For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of the total genome sequence, and subsequently the fact that at least 90% of the human genome is actively transcribed.Thus, the human transcriptome was found to be more complex than a collection of protein-coding genes and their splice variants. Although initially argued to be spurious transcriptional noise or accumulated evolutionary debris arising from the early assembly of genes and/or the insertion of mobile genetic elements, recent evidence suggests that the non-coding RNAs (ncRNAs) may play major biological roles in cellular development, physiology and pathologies, including cancer.
ER -
ŠÁNA, Jiří, Petra FALTEJSKOVÁ, Marek SVOBODA a Ondřej SLABÝ. Novel classes of non-coding RNAs and cancer. \textit{Journal of Translational Medicine}. London, England: BIOMED CENTRAL LTD, 2012, roč.~10, May, s.~''nestránkováno'', 21 s. ISSN~1479-5876. Dostupné z: https://dx.doi.org/10.1186/1479-5876-10-103.
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