Differential effects of modafinil, methamphetamine, and MDMA on
agonistic behavior in male mice

J 2012

Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

MÁCHALOVÁ, Alena; Karel ŠLAIS; Dagmar VRSKOVA a Alexandra ŠULCOVÁ

Základní údaje

Originální název

Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice

Autoři

MÁCHALOVÁ, Alena ; Karel ŠLAIS; Dagmar VRSKOVA a Alexandra ŠULCOVÁ

Vydání

Pharmacology Biochemistry and Behavior, Oxford, UK, Elsevier Science Inc. 2012, 0091-3057

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.608

Kód RIV

RIV/00216224:14740/12:00060033

Organizační jednotka

Středoevropský technologický institut

DOI

https://doi.org/10.1016/j.pbb.2012.04.013

UT WoS

000306776000006

Klíčová slova anglicky

Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice

Štítky

ok, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 4. 2013 08:09, Olga Křížová

Anotace

V originále

The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

MSM0021622404, záměr

Název: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Citovat

MÁCHALOVÁ, Alena; Karel ŠLAIS; Dagmar VRSKOVA a Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. Pharmacology Biochemistry and Behavior. Oxford, UK: Elsevier Science Inc., 2012, roč. 102, č. 2, s. 215-223. ISSN 0091-3057. Dostupné z: https://doi.org/10.1016/j.pbb.2012.04.013.

@article{983340,
   author = {Máchalová, Alena and Šlais, Karel and Vrskova, Dagmar and Šulcová, Alexandra},
   article_location = {Oxford, UK},
   article_number = {2},
   doi = {https://doi.org/10.1016/j.pbb.2012.04.013},
   keywords = {Psychostimulant; Modafinill; Methamphetamine; MDMA; Agnostic behavior; Mice},
   language = {eng},
   issn = {0091-3057},
   journal = {Pharmacology Biochemistry and Behavior},
   title = {Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice},
   url = {http://www.sciencedirect.com/science/article/pii/S0091305712001232},
   volume = {102},
   year = {2012}
}

TY  - JOUR
ID  - 983340
AU  - Máchalová, Alena - Šlais, Karel - Vrskova, Dagmar - Šulcová, Alexandra
PY  - 2012
TI  - Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
JF  - Pharmacology Biochemistry and Behavior
VL  - 102
IS  - 2
SP  - 215-223
EP  - 215-223
PB  - Elsevier Science Inc.
SN  - 00913057
KW  - Psychostimulant
KW  - Modafinill
KW  - Methamphetamine
KW  - MDMA
KW  - Agnostic behavior
KW  - Mice
UR  - http://www.sciencedirect.com/science/article/pii/S0091305712001232
L2  - http://www.sciencedirect.com/science/article/pii/S0091305712001232
N2  - The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or “ecstasy”) in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates)were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with nonaggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA).
ER  -

MÁCHALOVÁ, Alena; Karel ŠLAIS; Dagmar VRSKOVA a Alexandra ŠULCOVÁ. Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice. \textit{Pharmacology Biochemistry and Behavior}. Oxford, UK: Elsevier Science Inc., 2012, roč.~102, č.~2, s.~215-223. ISSN~0091-3057. Dostupné z: https://doi.org/10.1016/j.pbb.2012.04.013.

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