SLABÝ, Ondřej. MicroRNAs and Genetic Polymorphisms in Cancer. In Ondrej Slaby. MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets. New York: Nova Science Publishers, Inc., 2012, p. 21-28. ISBN 978-1-61324-514-9.
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Basic information
Original name MicroRNAs and Genetic Polymorphisms in Cancer
Authors SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution).
Edition New York, MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets, p. 21-28, 8 pp. 2012.
Publisher Nova Science Publishers, Inc.
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14740/12:00060174
Organization unit Central European Institute of Technology
ISBN 978-1-61324-514-9
Keywords in English microRNAs; cancer; genetic polymorphisms
Tags ok, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 13/3/2013 13:28.
Abstract
Single nucleotide polymorphisms (SNPs) may occur at the level of miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or the mature miRNA sequence. Such SNPs may be functional in the biogenesis and action of the mature miRNA. SNPs located to predicted miRNA target sites within 3' UTR of mRNAs have the potential to affect the efficiency of miRNA binding on its target site, create or destroy binding sites. Resulting gene deregulation can involve changes in phenotype and be eventually critical not only for the susceptibility and the onset of cancer, but also for its prognosis and therapy response prediction.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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