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@article{984838,
author = {Kohoutek, Jiří and Blažek, Dalibor},
article_location = {London},
article_number = {12},
doi = {http://dx.doi.org/10.1186/1747-1028-7-12},
keywords = {Transcription; Posttranscriptional processing; DNA damage; P-TEFb; Cyclin L; CTD code; CTD kinase; Phosphorylation of serine 2; BRCA1; ATR; FANCI; FANCD2},
language = {eng},
issn = {1747-1028},
journal = {Cell Division},
title = {Cyclin K goes with Cdk12 and Cdk13},
url = {http://www.celldiv.com/content/7/1/12},
volume = {7},
year = {2012}
}
TY - JOUR
ID - 984838
AU - Kohoutek, Jiří - Blažek, Dalibor
PY - 2012
TI - Cyclin K goes with Cdk12 and Cdk13
JF - Cell Division
VL - 7
IS - 12
SP - "nestránkováno"
EP - "nestránkováno"
PB - Biomed Central Ltd.
SN - 17471028
KW - Transcription
KW - Posttranscriptional processing
KW - DNA damage
KW - P-TEFb
KW - Cyclin L
KW - CTD code
KW - CTD kinase
KW - Phosphorylation of serine 2
KW - BRCA1
KW - ATR
KW - FANCI
KW - FANCD2
UR - http://www.celldiv.com/content/7/1/12
L2 - http://www.celldiv.com/content/7/1/12
N2 - The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins’ functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.
ER -
KOHOUTEK, Jiří a Dalibor BLAŽEK. Cyclin K goes with Cdk12 and Cdk13. \textit{Cell Division}. London: Biomed Central Ltd., 2012, roč.~7, č.~12, s.~''nestránkováno'', 10 s. ISSN~1747-1028. Dostupné z: https://dx.doi.org/10.1186/1747-1028-7-12.
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