MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS
PÁVEK, Nikolas, Jolana LIPKOVÁ, Petr NĚMEC, Jindra GATTEROVA, Miroslav SOUČEK, Anna VAŠKŮ and Monika GOLDBERGOVÁ. MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS. In 8th International Congress on Autoimmunity. 2012. |
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Basic information | |
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Original name | MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS |
Name in Czech | Chemokiny MCP-1 a RANTES a faktory popisující revmatoidní artritidu |
Name (in English) | MCP-1 AND RANTES CHEMOKINES AND FACTORS DESCRIBING RHEUMATOID ARTHRITIS |
Authors | PÁVEK, Nikolas, Jolana LIPKOVÁ, Petr NĚMEC, Jindra GATTEROVA, Miroslav SOUČEK, Anna VAŠKŮ and Monika GOLDBERGOVÁ. |
Edition | 8th International Congress on Autoimmunity, 2012. |
Other information | |
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Type of outcome | Conference abstract |
Confidentiality degree | is not subject to a state or trade secret |
Keywords (in Czech) | chemokiny, MCP-1, RANTES, IL-15, IL-10, revmatoidní artritida |
Keywords in English | chemokines, MCP-1,RANTES, IL-15, IL-10, rheumatoid arthritis |
Tags | International impact |
Changed by | Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 25/3/2013 14:58. |
Abstract |
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The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractant involved in immunoregulatory and inflammatory processes inclusive rheumatoid arthritis. In our study we found a significant increase in the prevalence of the heterozygous variant of the -855C/G MCP-1 polymorphism compared to homozygous variants in the IgM RF-positive subgroup of RA patients. Furthermore, an association of RANTES -403 G/A promoter polymorphism to circulating levels of IL15 and IL10 was found. |
Abstract (in Czech) |
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Chemokiny MCP-1/CCL2 a RANTES/CCL5 jsou chemoatraktanty zapojené do imunoregulačních a zánětlivých procesů mimo jiné u revmatoidní artritidy. V naší studii jsme prokázali zvýšený výskyt heterozygotní varianty -855C/G MCP-1 ve srovnání s homozygotními variantami u IgM RF-pozitivní podskupiny pacientů s revmatoidní artritidou. Dále jsme prokázali asociaci polymorfismu -403 G/A u RANTES s hladinami IL15 a IL10 v cirkulaci. |
Abstract (in English) |
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The MCP-1/CCL2 as well as RANTES/CCL5 chemokines are potent chemoattractant involved in immunoregulatory and inflammatory processes incisive rheumatoid arthritis. Inour study we found a significant increase in the prevalence of the heterozygous variant of the -855C/G MCP-1 polymorphism compared to homozygous variants in the IgM RF-positive subgroup of RA patients. Furthermore, an association of RANTES -403 G/A promoter polymorphism to circulating levels of IL15 and IL10 was found. |
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MUNI/A/0839/2011, interní kód MU | Name: Patofyziologické aspekty vybraných genotypů a fenotypů komplexních nemocí (Acronym: Patofyziologie komplexních nemocí) |
Investor: Masaryk University, Category A |
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