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@article{987346,
author = {Sláma, J. and Dundr, P. and Dušek, Ladislav and Fischerová, D. and Pinkavová, I. and Zikan, M. and Vrzackova, P. and Kojanova, M. and Cibula, D.},
article_location = {SAN DIEGO},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.ygyno.2012.02.010},
keywords = {Cervical cancer; Sentinel lymph node; Neoadjuvant chemotherapy; Radical hysterectomy},
language = {eng},
issn = {0090-8258},
journal = {Gynecologic Oncology},
title = {Sentinel lymph node status in patients with locally advanced cervical cancers and impact of neoadjuvant chemotherapy},
volume = {125},
year = {2012}
}
TY - JOUR
ID - 987346
AU - Sláma, J. - Dundr, P. - Dušek, Ladislav - Fischerová, D. - Pinkavová, I. - Zikan, M. - Vrzackova, P. - Kojanova, M. - Cibula, D.
PY - 2012
TI - Sentinel lymph node status in patients with locally advanced cervical cancers and impact of neoadjuvant chemotherapy
JF - Gynecologic Oncology
VL - 125
IS - 2
SP - 303-306
EP - 303-306
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 00908258
KW - Cervical cancer
KW - Sentinel lymph node
KW - Neoadjuvant chemotherapy
KW - Radical hysterectomy
N2 - Objectives. Neoadjuvant chemotherapy (NAC) is used in locally advanced cervical cancers with the aim to decrease the size of the tumor and to allow for less radical surgery. Despite of the fact that the high response rate of the tumor has been well established, the impact of NAC on sentinel lymph node (SN) detection and status has not been explored to date. Methods. Our study included 82 patients with locally advanced cervical cancers (FIGO IB1 >3 cm, IB2, IIA2 and selected IIB) out of which 51 patients were referred to SN biopsy prior to NAC and 31 patients to radical surgical procedure including SN biopsy after three courses of "dose density" NAC. In both groups, the prevalence of macrometastases, micrometastases and isolated tumor cells (ITC) in SN was compared. Results. The total of 179 SNs was evaluated. SN detection rate in the whole cohort reached 87.8% per patient and 60.9% bilaterally, without significant difference between both groups. In the group with upfront SN biopsy prior to NAC the prevalence of macrometastases, micrometastases and ITC amounted to 43.1% (22/51), 7.8% (4/51) and 7.8% (4/51) respectively. In the group with SN biopsy after previous NAC, macrometastases were detected in 22.6 (7/31) of patients in SN, whereas there was only one micrometastasis and no ITC detected in that group. Conclusions. Neoadjuvant chemotherapy did not influence the detection rate of SNs, yet it was associated with significantly reduced prevalence of metastatic involvement of SNs, especially almost completely eliminating low volume disease.
ER -
SLÁMA, J., P. DUNDR, Ladislav DUŠEK, D. FISCHEROVÁ, I. PINKAVOVÁ, M. ZIKAN, P. VRZACKOVA, M. KOJANOVA a D. CIBULA. Sentinel lymph node status in patients with locally advanced cervical cancers and impact of neoadjuvant chemotherapy. \textit{Gynecologic Oncology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2012, roč.~125, č.~2, s.~303-306. ISSN~0090-8258. Dostupné z: https://dx.doi.org/10.1016/j.ygyno.2012.02.010.
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