Antidepressant properties of the 5-HT(4) receptor partial
agonist, SL65.0155: Behavioral and neurochemical studies in
rats

J 2009

Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats

TAMBURELLA, Alessandra; Vincenzo MICALE; Andrea NAVARRIA a Filippo DRAGO

Základní údaje

Originální název

Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats

Autoři

TAMBURELLA, Alessandra; Vincenzo MICALE; Andrea NAVARRIA a Filippo DRAGO

Vydání

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, OXFORD, PERGAMON-ELSEVIER SCIENCE LTD, 2009, 0278-5846

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.823

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.pnpbp.2009.07.001

UT WoS

000270285500017

Klíčová slova anglicky

5-HT(4) receptors; Forced swim test; Neurotrophic factors; SL65.0155

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 8. 2012 07:27, Olga Křížová

Anotace

V originále

This study was undertaken to investigate the potential antidepressant-like properties of SL65.0155, a serotonin 5-HT(4) receptor partial agonist, in male rats of the Wistar strain tested in the forced swim test (FST), an experimental model widely used to assess antidepressant-like activity. The expression of hippocampal neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), the phosphorilated cAMP response element-binding protein (p-CREB), the B cell lymphoma-2 (Bcl-2), the Bax and the vascular endothelium growth factor (VEGF) were also evaluated by Western Blot analysis. Different groups of rats received intraperitoneally (i.p.) injections of SL65.0155 (0.1, 0.5 and 1 mg/kg), clomipramine (50 mg/kg), citalopram (15 mg/kg) or vehicle, respectively, 24, 5 and 1 h prior to the FST. Compared to the control group, SL65.0155 (0.5 and 1 mg/kg), clomipramine or citalopram injected animals showed an increased swimming and climbing behavior and reduced immobility time in the FST. Interestingly, this effect was not due to changes in the locomotor activity since all treated groups failed to show any change in motor ability as assessed in the open field test. Western blot analysis of hippocampal homogenates showed an enhancement of p-CREB, BDNF Bcl-2 and VEGF protein levels in SL65.0155 treated groups, but not in citalopram or clomipramine treated groups, used here as positive control. No change was found in Bax expression in any treated group. These findings give further support to the hypothesis that the stimulation of serotonin 5-HT(4) receptors may be a therapeutic target for depression.

Citovat

TAMBURELLA, Alessandra; Vincenzo MICALE; Andrea NAVARRIA a Filippo DRAGO. Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2009, roč. 33, č. 7, s. 1205-1210. ISSN 0278-5846. Dostupné z: https://doi.org/10.1016/j.pnpbp.2009.07.001.

@article{988263,
   author = {Tamburella, Alessandra and Micale, Vincenzo and Navarria, Andrea and Drago, Filippo},
   article_location = {OXFORD},
   article_number = {7},
   doi = {https://doi.org/10.1016/j.pnpbp.2009.07.001},
   keywords = {5-HT(4) receptors; Forced swim test; Neurotrophic factors; SL65.0155},
   language = {eng},
   issn = {0278-5846},
   journal = {PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY},
   title = {Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats},
   volume = {33},
   year = {2009}
}

TY  - JOUR
ID  - 988263
AU  - Tamburella, Alessandra - Micale, Vincenzo - Navarria, Andrea - Drago, Filippo
PY  - 2009
TI  - Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats
JF  - PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
VL  - 33
IS  - 7
SP  - 1205-1210
EP  - 1205-1210
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - 5-HT(4) receptors
KW  - Forced swim test
KW  - Neurotrophic factors
KW  - SL65.0155
N2  - This study was undertaken to investigate the potential antidepressant-like properties of SL65.0155, a serotonin 5-HT(4) receptor partial agonist, in male rats of the Wistar strain tested in the forced swim test (FST), an experimental model widely used to assess antidepressant-like activity. The expression of hippocampal neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), the phosphorilated cAMP response element-binding protein (p-CREB), the B cell lymphoma-2 (Bcl-2), the Bax and the vascular endothelium growth factor (VEGF) were also evaluated by Western Blot analysis. Different groups of rats received intraperitoneally (i.p.) injections of SL65.0155 (0.1, 0.5 and 1 mg/kg), clomipramine (50 mg/kg), citalopram (15 mg/kg) or vehicle, respectively, 24, 5 and 1 h prior to the FST. Compared to the control group, SL65.0155 (0.5 and 1 mg/kg), clomipramine or citalopram injected animals showed an increased swimming and climbing behavior and reduced immobility time in the FST. Interestingly, this effect was not due to changes in the locomotor activity since all treated groups failed to show any change in motor ability as assessed in the open field test. Western blot analysis of hippocampal homogenates showed an enhancement of p-CREB, BDNF Bcl-2 and VEGF protein levels in SL65.0155 treated groups, but not in citalopram or clomipramine treated groups, used here as positive control. No change was found in Bax expression in any treated group. These findings give further support to the hypothesis that the stimulation of serotonin 5-HT(4) receptors may be a therapeutic target for depression.
ER  -

TAMBURELLA, Alessandra; Vincenzo MICALE; Andrea NAVARRIA a Filippo DRAGO. Antidepressant properties of the 5-HT(4) receptor partial agonist, SL65.0155: Behavioral and neurochemical studies in rats. \textit{PROGRESS IN NEURO-PSYCHOPHARMACOLOGY \&{}amp; BIOLOGICAL PSYCHIATRY}. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD, 2009, roč.~33, č.~7, s.~1205-1210. ISSN~0278-5846. Dostupné z: https://doi.org/10.1016/j.pnpbp.2009.07.001.

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