Altered responses of dopamine D3 receptor null mice to
excitotoxic or anxiogenic stimuli: Possible involvement of the
endocannabinoid and endovanilloid systems

J 2009

Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO et al.

Základní údaje

Originální název

Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems

Autoři

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO; Filippo DRAGO a Vincenzo DI MARZO

Vydání

NEUROBIOLOGY OF DISEASE, SAN DIEGO, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009, 0969-9961

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.518

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.nbd.2009.06.015

UT WoS

000273016900008

Klíčová slova anglicky

Endocannabinoid; Endovanilloid; Dopamine; D3 receptors; Knock-out mice; Epilepsy; Anxiety

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 8. 2012 07:35, Olga Křížová

Anotace

V originále

Dopamine and the endocannabinoids, anandamide and 2-arachidonoylglycerol, interact at several levels in the brain, with the involvement of both cannabinoid CB(1) receptors and transient receptor potential vanilloid type-1 (TRPV1) channels (which are alternative anandamide receptors). Using pharmacological, immunohistochemical and analytical approaches, we investigated the response of dopamine D(3) receptor null (D3R((-/-))) mice in models of epilepsy and anxiety, in relation to their brain endocannabinoid and endovanilloid tone. Compared to wild-type mice, D3R((-/-)) mice exhibited a delayed onset of clonic seizures, enhanced survival time, reduced mortality rate and more sensitivity to anticonvulsant effects of diazepam after intraperitoneal administration of picrotoxin (7 mg/kg), and a less anxious-like behaviour in the elevated plus maze test. D3R((-/-)) mice also exhibited different endocannabinoid and TRPV1, but not CB(1), levels in the hippocampus, nucleus accumbens, amygdala and striatum. Given the role played by CB(1) and TRPV1 in neuroprotection and anxiety, and based on data obtained here with pharmacological tools, we suggest that the alterations of endocannabinoid and endovanilloid tone found in D3R((-/-)) mice might account for part of their altered responses to excitotoxic and anxiogenic stimuli. (C) 2009 Elsevier Inc. All rights reserved.

Citovat

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO; Filippo DRAGO a Vincenzo DI MARZO. Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems. NEUROBIOLOGY OF DISEASE. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009, roč. 36, č. 1, s. 70-80. ISSN 0969-9961. Dostupné z: https://doi.org/10.1016/j.nbd.2009.06.015.

@article{988264,
   author = {Micale, Vincenzo and Cristino, Luigia and Tamburella, Alessandra and Petrosino, Stefania and Leggio, Gian Marco and Drago, Filippo and Di Marzo, Vincenzo},
   article_location = {SAN DIEGO},
   article_number = {1},
   doi = {https://doi.org/10.1016/j.nbd.2009.06.015},
   keywords = {Endocannabinoid; Endovanilloid; Dopamine; D3 receptors; Knock-out mice; Epilepsy; Anxiety},
   language = {eng},
   issn = {0969-9961},
   journal = {NEUROBIOLOGY OF DISEASE},
   title = {Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems},
   volume = {36},
   year = {2009}
}

TY  - JOUR
ID  - 988264
AU  - Micale, Vincenzo - Cristino, Luigia - Tamburella, Alessandra - Petrosino, Stefania - Leggio, Gian Marco - Drago, Filippo - Di Marzo, Vincenzo
PY  - 2009
TI  - Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems
JF  - NEUROBIOLOGY OF DISEASE
VL  - 36
IS  - 1
SP  - 70-80
EP  - 70-80
PB  - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN  - 09699961
KW  - Endocannabinoid
KW  - Endovanilloid
KW  - Dopamine
KW  - D3 receptors
KW  - Knock-out mice
KW  - Epilepsy
KW  - Anxiety
N2  - Dopamine and the endocannabinoids, anandamide and 2-arachidonoylglycerol, interact at several levels in the brain, with the involvement of both cannabinoid CB(1) receptors and transient receptor potential vanilloid type-1 (TRPV1) channels (which are alternative anandamide receptors). Using pharmacological, immunohistochemical and analytical approaches, we investigated the response of dopamine D(3) receptor null (D3R((-/-))) mice in models of epilepsy and anxiety, in relation to their brain endocannabinoid and endovanilloid tone. Compared to wild-type mice, D3R((-/-)) mice exhibited a delayed onset of clonic seizures, enhanced survival time, reduced mortality rate and more sensitivity to anticonvulsant effects of diazepam after intraperitoneal administration of picrotoxin (7 mg/kg), and a less anxious-like behaviour in the elevated plus maze test. D3R((-/-)) mice also exhibited different endocannabinoid and TRPV1, but not CB(1), levels in the hippocampus, nucleus accumbens, amygdala and striatum. Given the role played by CB(1) and TRPV1 in neuroprotection and anxiety, and based on data obtained here with pharmacological tools, we suggest that the alterations of endocannabinoid and endovanilloid tone found in D3R((-/-)) mice might account for part of their altered responses to excitotoxic and anxiogenic stimuli. (C) 2009 Elsevier Inc. All rights reserved.
ER  -

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO; Filippo DRAGO a Vincenzo DI MARZO. Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems. \textit{NEUROBIOLOGY OF DISEASE}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009, roč.~36, č.~1, s.~70-80. ISSN~0969-9961. Dostupné z: https://doi.org/10.1016/j.nbd.2009.06.015.

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