Enhanced cognitive performance of dopamine D3 receptor

J 2010

Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO et al.

Základní údaje

Originální název

Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems

Autoři

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO; Vincenzo DI MARZO a Filippo DRAGO

Vydání

PHARMACOLOGICAL RESEARCH, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2010, 1043-6618

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.612

Označené pro přenos do RIV

DOI

https://doi.org/10.1016/j.phrs.2010.02.003

UT WoS

000277883200009

Klíčová slova anglicky

Dopamine; D3 receptor; CB(1) receptors; Rimonabant; Memory; TRPV1

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 8. 2012 08:34, Olga Křížová

Anotace

V originále

Increasing evidence suggests a pivotal role of the D3 receptor (D3R) in cognitive processes and the involvement of endocannabinoid/endovanilloid signaling in the pathophysiology of neurodegenerative disorders such as Alzheimer's disease. This study was undertaken to investigate both the basal and beta-amyloid peptide 1-42 (BAP 1-42)-impaired cognitive performance of D3R((-/-)) mice, and the role therein of endocannabinoids/endovanilloids. D3R((-/-)) mice were either untreated or injected i.c.v. with 400 pMol BAP 1-42 or vehicle to be tested 14 days later in a step-through passive-avoidance paradigm. The CB(1) receptor antagonist, rimonabant (1 mg/kg), or the transient receptor potential vanilloid-type 1 channel (TRPV1) antagonist SB366791, were injected intraperitoneally for 11 or 7 days. The retention test was performed 1,7 and 14 days after the learning trial. Wild-type (WT) mice were subjected to the same procedures. D3R((-/-)) mice exhibited a better basal cognitive performance as compared to WT mice (p < 0.001), which was reversed by TRPV1 antagonism. BAP 1-42 induced a pronounced worsening of the passive-avoidance response in all tests and in both genotypes (p < 0.001). Rimonabant treatment never affected the cognitive performance of healthy mice, but fully counteracted BAP 1-42-induced amnesic effects in both D3R((-/-)) and WT mice only when administered for 11 days, whereas, when administered for 7 days, only transiently affected WT mice and caused more prolonged cognitive ameliorations in D3R((-/-)) mice. These results support the involvement of D3R and TRPV1 in cognitive processes and the concept that A beta peptides inhibit memory retention in mice through the involvement of endocannabinoids.

Citovat

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO; Vincenzo DI MARZO a Filippo DRAGO. Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems. PHARMACOLOGICAL RESEARCH. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2010, roč. 61, č. 6, s. 531-536. ISSN 1043-6618. Dostupné z: https://doi.org/10.1016/j.phrs.2010.02.003.

@article{988715,
   author = {Micale, Vincenzo and Cristino, Luigia and Tamburella, Alessandra and Petrosino, Stefania and Leggio, Gian Marco and Di Marzo, Vincenzo and Drago, Filippo},
   article_location = {London},
   article_number = {6},
   doi = {https://doi.org/10.1016/j.phrs.2010.02.003},
   keywords = {Dopamine; D3 receptor; CB(1) receptors; Rimonabant; Memory; TRPV1},
   language = {eng},
   issn = {1043-6618},
   journal = {PHARMACOLOGICAL RESEARCH},
   title = {Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems},
   volume = {61},
   year = {2010}
}

TY  - JOUR
ID  - 988715
AU  - Micale, Vincenzo - Cristino, Luigia - Tamburella, Alessandra - Petrosino, Stefania - Leggio, Gian Marco - Di Marzo, Vincenzo - Drago, Filippo
PY  - 2010
TI  - Enhanced cognitive performance of dopamine D3 receptor "knock-out" mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems
JF  - PHARMACOLOGICAL RESEARCH
VL  - 61
IS  - 6
SP  - 531-536
EP  - 531-536
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10436618
KW  - Dopamine
KW  - D3 receptor
KW  - CB(1) receptors
KW  - Rimonabant
KW  - Memory
KW  - TRPV1
N2  - Increasing evidence suggests a pivotal role of the D3 receptor (D3R) in cognitive processes and the involvement of endocannabinoid/endovanilloid signaling in the pathophysiology of neurodegenerative disorders such as Alzheimer's disease. This study was undertaken to investigate both the basal and beta-amyloid peptide 1-42 (BAP 1-42)-impaired cognitive performance of D3R((-/-)) mice, and the role therein of endocannabinoids/endovanilloids. D3R((-/-)) mice were either untreated or injected i.c.v. with 400 pMol BAP 1-42 or vehicle to be tested 14 days later in a step-through passive-avoidance paradigm. The CB(1) receptor antagonist, rimonabant (1 mg/kg), or the transient receptor potential vanilloid-type 1 channel (TRPV1) antagonist SB366791, were injected intraperitoneally for 11 or 7 days. The retention test was performed 1,7 and 14 days after the learning trial. Wild-type (WT) mice were subjected to the same procedures. D3R((-/-)) mice exhibited a better basal cognitive performance as compared to WT mice (p < 0.001), which was reversed by TRPV1 antagonism. BAP 1-42 induced a pronounced worsening of the passive-avoidance response in all tests and in both genotypes (p < 0.001). Rimonabant treatment never affected the cognitive performance of healthy mice, but fully counteracted BAP 1-42-induced amnesic effects in both D3R((-/-)) and WT mice only when administered for 11 days, whereas, when administered for 7 days, only transiently affected WT mice and caused more prolonged cognitive ameliorations in D3R((-/-)) mice. These results support the involvement of D3R and TRPV1 in cognitive processes and the concept that A beta peptides inhibit memory retention in mice through the involvement of endocannabinoids.
ER  -

MICALE, Vincenzo; Luigia CRISTINO; Alessandra TAMBURELLA; Stefania PETROSINO; Gian Marco LEGGIO; Vincenzo DI MARZO a Filippo DRAGO. Enhanced cognitive performance of dopamine D3 receptor ''knock-out'' mice in the step-through passive-avoidance test: Assessing the role of the endocannabinoid/endovanilloid systems. \textit{PHARMACOLOGICAL RESEARCH}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2010, roč.~61, č.~6, s.~531-536. ISSN~1043-6618. Dostupné z: https://doi.org/10.1016/j.phrs.2010.02.003.

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